SCHEMBL25745

SCHEMBL25745

O=C(CI)NCCNc1cccc2c(S(=O)(=O)O)cccc12

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 2/20 0.44
CA9 Q16790 2/20 0.44
CA4 P22748 1/20 0.44
CA7 P43166 1/20 0.44
CA14 Q9ULX7 1/20 0.44
PRKAG1 P54619 1/20 0.42
PRKAA1 Q13131 1/20 0.42
PRKAB1 Q9Y478 1/20 0.42
TTR P02766 1/20 0.41
CYP1A2 P05177 2/20 0.39
NPY5R Q15761 1/20 0.36
KDM4E B2RXH2 1/20 0.35
ALDH1A1 P00352 1/20 0.35
GAA P10253 1/20 0.35
MAPT P10636 1/20 0.35
HPGD P15428 1/20 0.35
TSHR P16473 1/20 0.35
HSD17B10 Q99714 1/20 0.35
BCHE P06276 1/20 0.34
NSD2 O96028 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29358898 1.00 CA12 (0.44) CA12CA9CA4CA7CA14
SCHEMBL29355645 1.00 CA12 (0.44) CA12CA9CA4CA7CA14
SCHEMBL134374 0.88 CA12 (0.47) CA12CA9CA4CA7CA14
SCHEMBL21347987 0.87 CA12 (0.47) CA12CA9CA4CA7CA14
SCHEMBL9626308 0.87 CA12 (0.44) CA12CA9CA4CA7CA14
SCHEMBL21347989 0.87 CA12 (0.47) CA12CA9CA4CA7CA14
SCHEMBL22793508 0.86 TTR (0.43) CA12CA9CA4CA7CA14
SCHEMBL7813627 0.85 PRKAG1 (0.39) CA12CA9CA4CA7CA14
SCHEMBL6128009 0.84 CA12 (0.63) CA12CA9CA4CA7CA14
SCHEMBL3036841 0.83 TTR (0.49) CA12CA9CA4CA7CA14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 5416 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12637679-B2 Aptamer based system to quantify anti-thrombin III in blood UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2026-05-26 US claimed
US-20250341524-A1 FLUORESCENTLY-LABELED F-ACTIN PROTEIN BIOSENSORS AND METHODS OF HIGH-THROUGHPUT DRUG DISCOVERY UNIV ARIZONA (US) 2025-11-06 US claimed
US-12326450-B2 Kits, methods and their uses for detecting cell-cell interactions in a sample FASTBASE SOLUTIONS SL (ES) 2025-06-10 US claimed
US-20250084452-A1 BIOLOGICAL INDICATOR FOR DETERMINING THE EFFICACY OF A STERILIZATION PROCESS AND METHODS OF USE TERRAGENE LLC 2025-03-13 US claimed
CN-119587685-A Cancer vaccine loaded with hapten substance modified cancer cells and/or tumor tissue lysate components and preparation method thereof 苏州尔生生物医药有限公司 2025-03-11 CN claimed
US-20240168032-A1 GLUCOSE BIOSENSORS AND USES THEREOF UNIV DUKE (US) 2024-05-23 US claimed
EP-3377898-B1 THERMOSTABLE GLUCOSE BIOSENSORS AND USES THEREOF UNIV DUKE (US) 2024-05-01 EP claimed
EP-3377904-B1 UREA BIOSENSORS AND USES THEREOF UNIV DUKE (US) 2024-05-01 EP claimed
EP-3377897-B1 LACTATE BIOSENSORS AND USES THEREOF UNIV DUKE (US) 2024-05-01 EP claimed
EP-4355908-A1 A METHOD TO AMPLIFY AND DETECT TARGET NUCLEIC ACIDS WITH VERY HIGH SPECIFICITY AND SENSITIVITY Obront Biotech Private Limited (IN) 2024-04-24 EP claimed
US-20020197630-A1 Systems and methods for high throughput genetic analysis CALIPER LIFE SCIENCES, INC. 2002-12-26 US claimed
US-20020168692-A1 Biosensor detector array IMPERIAL COLLEGE INNOVATIONS (GB) 2002-11-14 US claimed
WO-2002083952-A1 SYSTEMS AND METHODS FOR HIGH THROUGHPUT GENETIC ANALYSIS CALIPER TECHNOLOGIES CORP. (US) 2002-10-24 WO claimed
WO-2001004357-A9 GENERIC SBE-FRET PROTOCOL WHITEHEAD BIOMEDICAL INST (US) 2002-07-25 WO claimed
US-20020009742-A1 Method and composition for the manufacture of molecular beacons U-DUB PRODUCTIONS, LLC. 2002-01-24 US claimed
WO-2001083820-A1 METHODS AND COMPOSITIONS FOR THE MANUFACTURE OF MOLECULAR BEACONS MONTCLAIR GROUP (US) 2001-11-08 WO claimed
WO-2001004357-A2 GENERIC SBE-FRET PROTOCOL WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) 2001-01-18 WO claimed
WO-2000077520-A1 LABELLING OF PEPTIDES AND PROTEINS PROTEOSYS AG (DE) 2000-12-21 WO claimed
EP-1059531-A1 Labelling of peptides and proteins Nordheim, Alfred, Prof. Dr. (DE) 2000-12-13 EP claimed
US-4942136-A Method for production of fluorescence-labeled Fab' AGENCY OF INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 1990-07-17 US claimed