Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methamphetamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 1.00 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 1.00 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methamphetamine SCHEMBL15094315 | 1.00 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| Methamphetamine SCHEMBL20211416 | 1.00 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| Methamphetamine SCHEMBL17008774 | 1.00 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| Levmetamfetamine SCHEMBL727412 | 1.00 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| Methamphetamine SCHEMBL42615 | 1.00 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| Methamphetamine SCHEMBL4781849 | 1.00 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| Methamphetamine SCHEMBL13747483 | 1.00 | SIGMAR1 (1.00) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| Methamphetamine SCHEMBL23035463 | 0.98 | SIGMAR1 (0.95) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| Methamphetamine SCHEMBL9114797 | 0.98 | SIGMAR1 (0.95) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| Methamphetamine SCHEMBL11415206 | 0.98 | SIGMAR1 (0.95) | SIGMAR1TAAR1SLC18A2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 32906 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260144787-A1 | COMPOSITIONS AND METHODS FOR TREATING STIMULANT-INDUCED AGITATION | MARSHALL UNIVERSITY RESEARCH CORPORATION (US) | 2026-05-28 | — | — | US | claimed |
| EP-4747639-A2 | BETA-GALACTOSIDASE ENZYME-BASED IMMUNOASSAY | Abbott Diagnostics Scarborough, Inc. (US) | 2026-05-27 | — | — | EP | claimed |
| CN-122094963-A | Cardioprotective lipids and methods of use | — | 2026-05-26 | — | — | CN | claimed |
| CN-122084580-A | Preparation method of nano-plasma super-surface biosensor and application of nano-plasma super-surface biosensor in detection of novel psychoactive substances | — | 2026-05-26 | — | — | CN | claimed |
| CN-121910745-B | Application of N-acetylneuraminic acid in preparation of drugs for treating methamphetamine addiction | JINAN UNIVERSITY (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-122072257-A | Method for rapidly detecting poison in blood | 中国科学院大连化学物理研究所 | 2026-05-22 | — | — | CN | claimed |
| US-20260140114-A1 | ASSAYS FOR ANTIMICROBIAL ACTIVITY AND APPLICATIONS THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2026-05-21 | — | — | US | claimed |
| US-20260141998-A1 | METHOD FOR TRACKING, VERIFYING, AND AUTHENTICATING MULTI-STAGE CHAIN OF CUSTODY | Courtfact, LLC (US) | 2026-05-21 | — | — | US | claimed |
| US-20260139032-A1 | ACTIVIN RECEPTOR TYPE IIB VARIANTS AND USES THEREOF | 35PHARMA INC (CA) | 2026-05-21 | — | — | US | claimed |
| CN-121431735-B | Characterization method of molecular weight and molecular weight distribution of crystalline polyaryletherketone | 吉林大学 | 2026-05-19 | — | — | CN | claimed |
| EP-0204954-A2 | Use of dopamine agonists for the manufacture of a medicament for the treatment of psychostimulant addiction | SANDOZ AG (CH) | 1986-12-17 | — | — | EP | claimed |
| EP-0201586-A1 | PROCESS FOR THE PREPARATION OF A BIBULOUS REACTIVE MEDIUM | MED-TECH PRODUCTS, INC. (US) | 1986-11-20 | — | — | EP | claimed |
| WO-1986003009-A1 | PROCESS FOR THE PREPARATION OF A BIBULOUS REACTIVE MEDIUM | MED-TECH PRODUCTS, INC. (US) | 1986-05-22 | — | — | WO | claimed |
| EP-0174342-A1 | BRAIN-SPECIFIC ANALOGUES OF CENTRALLY ACTING AMINES. | UNIV FLORIDA (US) | 1986-03-19 | — | — | EP | claimed |
| US-4557934-A | ALONG WITH A DIOL PYRROLIDONE OR AN AZACYCLOPENTAN-2-ONE | THE PROCTER & GAMBLE COMPANY (US) | 1985-12-10 | — | — | US | claimed |
| WO-1985003937-A1 | BRAIN-SPECIFIC ANALOGUES OF CENTRALLY ACTING AMINES | UNIVERSITY OF FLORIDA (US) | 1985-09-12 | — | — | WO | claimed |
| EP-0059057-A1 | Treatment of diarrhoea | BEECHAM GROUP PLC (GB) | 1982-09-01 | — | — | EP | claimed |
| US-4329281-A | AMPHETAMINE, METHAMPHETAMINE | HOFFMANN-LA ROCHE INC. (US) | 1982-05-11 | — | — | US | claimed |
| US-4175119-A | Composition and method to prevent accidental and intentional overdosage with psychoactive drugs | PORTER GARRY L | 1979-11-20 | — | — | US | claimed |
| US-3968245-A | Sympathomimetic topical and percutaneous administration with halogenated promoters | ALZA CORPORATION (US) | 1976-07-06 | — | — | US | claimed |