1-Naphthoquinoline

1-Naphthoquinoline

SCHEMBL4219087

Clc1cc2ccc3ccccc3c2nc1Cl.[Ir].[Ir].c1ccc2c(c1)ccc1cccnc12.c1ccc2c(c1)ccc1cccnc12.c1ccc2c(c1)ccc1cccnc12

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.64
CCR1 P32246 4/20 0.57
CCR8 P51685 4/20 0.57
L3MBTL1 Q9Y468 2/20 0.57
LMNA P02545 6/20 0.47
MAPT P10636 7/20 0.44
CYP3A4 P08684 5/20 0.44
KDM4E B2RXH2 5/20 0.44
TP53 P04637 4/20 0.44
SMN1; SMN2 Q16637 4/20 0.44
HSP90AA1 P07900 4/20 0.44
ALOX15 P16050 3/20 0.44
HTT P42858 3/20 0.44
TDP1 Q9NUW8 3/20 0.44
PMP22 Q01453 2/20 0.44
MMP9 P14780 2/20 0.44
MMP13 P45452 2/20 0.44
CCR5 P51681 2/20 0.44
HIF1A Q16665 2/20 0.44
GMNN O75496 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29442107 0.85 L3MBTL1 (0.50) ALDH1A1CCR1CCR8L3MBTL1LMNA
SCHEMBL29463567 0.84 CCR1 (0.62) ALDH1A1CCR1CCR8L3MBTL1LMNA
SCHEMBL5455738 0.84 CCR1 (0.62) ALDH1A1CCR1CCR8L3MBTL1LMNA
Hydrochloric Acid SCHEMBL17472453 0.82 CCR1 (0.61) ALDH1A1CCR1CCR8L3MBTL1LMNA
SCHEMBL5445004 0.82 CCR1 (0.61) ALDH1A1CCR1CCR8L3MBTL1LMNA
SCHEMBL29555797 0.82 CCR1 (0.61) ALDH1A1CCR1CCR8L3MBTL1LMNA
SCHEMBL29430447 0.82 CCR1 (0.61) ALDH1A1CCR1CCR8L3MBTL1LMNA
Hydrochloric Acid SCHEMBL17472452 0.82 CCR1 (0.61) ALDH1A1CCR1CCR8L3MBTL1LMNA
SCHEMBL16467196 0.82 CCR1 (0.61) ALDH1A1CCR1CCR8L3MBTL1LMNA
SCHEMBL29556537 0.82 CCR1 (0.61) ALDH1A1CCR1CCR8L3MBTL1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8664396-B2 Photoluminescent metal complexes for protein staining BIO-RAD LABORATORIES, INC. (US) 2014-03-04 US disclosed
EP-2217608-B1 PHOTOLUMINESCENT METAL COMPLEXES FOR PROTEIN STAINING BIO RAD LABORATORIES (US) 2012-09-05 EP disclosed
US-20090131640-A1 PHOTOLUMINESCENT METAL COMPLEXES FOR PROTEIN STAINING BIO-RAD LABORATORIES, INC. (US) 2009-05-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090131640-A1 PHOTOLUMINESCENT METAL COMPLEXES FOR PROTEIN STAINING NR2E3, NR2C2, ORC3 ALDH1A1 3522/4885CCR1 858/4885CCR8 1745/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.