Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | SSTR5 | P35346 | 11/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | MERTK | Q12866 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 2/20 | 0.42 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.42 |
| ▸ | RCOR1 | Q9UKL0 | 2/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3769722 | 0.95 | ACHE (0.55) | ACHEAPPSSTR5HRH1HTR2B | |
| SCHEMBL4231445 | 0.85 | APP (0.49) | ACHEAPPSSTR5HRH1HTR2B | |
| SCHEMBL3782856 | 0.85 | SSTR5 (0.62) | ACHEAPPSSTR5HRH1HTR2B | |
| SCHEMBL4231747 | 0.85 | APP (0.49) | ACHEAPPSSTR5HRH1HTR2B | |
| SCHEMBL4221954 | 0.85 | APP (0.49) | ACHEAPPSSTR5HRH1HTR2B | |
| SCHEMBL1878170 | 0.83 | SSTR5 (0.51) | ACHEAPPSSTR5HRH1HTR2B | |
| SCHEMBL3773308 | 0.83 | SSTR5 (0.64) | ACHEAPPSSTR5HRH1HTR2B | |
| SCHEMBL4233983 | 0.82 | SSTR5 (0.47) | ACHESSTR5HRH1HTR2B | |
| SCHEMBL4231286 | 0.81 | SSTR5 (0.56) | ACHESSTR5HRH1HTR2B | |
| SCHEMBL4230567 | 0.81 | SSTR5 (0.57) | ACHESSTR5HRH1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001867-B1 | PYRIMIDINE, QUINAZOLINE, PTERIDINE AND TRIAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2009-07-01 | — | — | EP | disclosed |