Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13778148 | 0.99 | PKM (0.49) | PKMLMNATRAP1ALDH1A1HTT | |
| Bromide SCHEMBL5827918 | 0.77 | HTT (0.49) | LMNAALDH1A1HTTSMN1; SMN2POLB | |
| SCHEMBL18138448 | 0.75 | PKM (0.56) | PKMLMNAALDH1A1HTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5828294 | 0.74 | KMT2A (0.54) | LMNAALDH1A1HTTSMN1; SMN2POLB | |
| SCHEMBL11101234 | 0.74 | PKM (0.44) | PKMLMNAALDH1A1HTTSMN1; SMN2 | |
| Bromide SCHEMBL6201598 | 0.74 | SMN1; SMN2 (0.50) | PKMLMNATRAP1ALDH1A1HTT | |
| SCHEMBL4222267 | 0.74 | PKM (0.55) | PKMLMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL13778225 | 0.74 | PKM (0.55) | PKMLMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL8073542 | 0.74 | PKM (0.59) | PKMLMNAALDH1A1HTTSMN1; SMN2 | |
| Bromide SCHEMBL26919058 | 0.73 | PKM (0.43) | PKMLMNATRAP1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7560491-B2 | Z-stilbenes derivatives and the pharmaceutical composition thereof | TAIPEI MEDICAL UNIVERSITY (TW) | 2009-07-14 | — | — | US | disclosed |
| US-20080096973-A1 | Z-stilbenes derivatives and the pharmaceutical composition thereof | TAIPEI MEDICAL UNIVERSITY (TW) | 2008-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080096973-A1 | Z-stilbenes derivatives and the pharmaceutical composition thereof | CCNB1, ZYX, H1-0 | PKM 2125/4885LMNA 1710/4885TRAP1 1277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.