Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | CDC25A | P30304 | 1/20 | 0.40 |
| ▸ | CDC25B | P30305 | 1/20 | 0.40 |
| ▸ | CDC25C | P30307 | 1/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ELOVL1 | Q9BW60 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4219458 | 0.82 | NPC1 (0.42) | LMNAMAPTRAB9AKMT2ANPC1 | |
| SCHEMBL4217249 | 0.82 | MAPT (0.52) | LMNAMAPTRAB9APARP1NPC1 | |
| SCHEMBL2433788 | 0.81 | CASR (0.56) | LMNAMAPTRAB9AKMT2ACDC25A | |
| SCHEMBL2433531 | 0.81 | CASR (0.56) | LMNAMAPTRAB9AKMT2ACDC25A | |
| SCHEMBL2433536 | 0.81 | CASR (0.56) | LMNAMAPTRAB9AKMT2ACDC25A | |
| SCHEMBL2462483 | 0.79 | CASR (0.55) | LMNAMAPTRAB9AKMT2ACDC25A | |
| SCHEMBL2462485 | 0.79 | CASR (0.55) | LMNAMAPTRAB9AKMT2ACDC25A | |
| SCHEMBL2464622 | 0.79 | CASR (0.55) | LMNAMAPTRAB9AKMT2ACDC25A | |
| SCHEMBL4213903 | 0.78 | RAB9A (0.41) | LMNAMAPTRAB9AKMT2APARP1 | |
| SCHEMBL4212296 | 0.77 | MAPT (0.44) | LMNAMAPTRAB9APARP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041103-A2 | DERIVATIVES OF UREA AND RELATED DIAMINES, METHODS FOR THEIR MANUFACTURE, AND USES THEREFOR | Galapagos SAS (FR) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008006625-A2 | DERIVATIVES OF UREA AND RELATED DIAMINES, METHODS FOR THEIR MANUFACTURE, AND USES THEREFOR | GALAPAGOS SAS (FR) | 2008-01-17 | — | — | WO | disclosed |