Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 11/20 | 0.75 |
| ▸ | CTSS | P25774 | 4/20 | 0.43 |
| ▸ | CTSL | P07711 | 3/20 | 0.41 |
| ▸ | CTSV | O60911 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5941609 | 1.00 | CTSK (0.75) | CTSKCTSSCTSLCTSVPOLB | |
| SCHEMBL5941601 | 1.00 | CTSK (0.75) | CTSKCTSSCTSLCTSVPOLB | |
| SCHEMBL4036982 | 1.00 | CTSK (0.75) | CTSKCTSSCTSLCTSVPOLB | |
| SCHEMBL5941709 | 1.00 | CTSK (0.75) | CTSKCTSSCTSLCTSVPOLB | |
| SCHEMBL5941706 | 1.00 | CTSK (0.75) | CTSKCTSSCTSLCTSVPOLB | |
| SCHEMBL4223964 | 0.99 | CTSK (0.76) | CTSKCTSSCTSLCTSVPOLB | |
| SCHEMBL5941303 | 0.99 | CTSK (0.76) | CTSKCTSSCTSLCTSVPOLB | |
| SCHEMBL4043209 | 0.99 | CTSK (0.76) | CTSKCTSSCTSLCTSVPOLB | |
| SCHEMBL5941302 | 0.99 | CTSK (0.76) | CTSKCTSSCTSLCTSVPOLB | |
| SCHEMBL5942270 | 0.97 | CTSK (0.76) | CTSKCTSSCTSLCTSVPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | disclosed |