Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 7/20 | 0.65 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.65 |
| ▸ | MMP3 | P08254 | 2/20 | 0.65 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | MMP12 | P39900 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4218242 | 1.00 | MMP13 (0.65) | MMP13ADAMTS4MMP3MMP8MMP12 | |
| SCHEMBL10166778 | 0.94 | MMP13 (0.66) | MMP13ADAMTS4MMP3MMP8MMP12 | |
| SCHEMBL4219902 | 0.93 | MMP13 (0.72) | MMP13ADAMTS4MMP3MMP8MMP12 | |
| SCHEMBL4219896 | 0.93 | MMP13 (0.72) | MMP13ADAMTS4MMP3MMP8MMP12 | |
| SCHEMBL5428072 | 0.92 | MMP13 (0.65) | MMP13ADAMTS4MMP3MMP8MMP12 | |
| SCHEMBL5427943 | 0.92 | MMP13 (0.65) | MMP13ADAMTS4MMP3MMP8MMP12 | |
| SCHEMBL4223408 | 0.92 | MMP13 (0.67) | MMP13ADAMTS4MMP3MMP8MMP12 | |
| SCHEMBL10167987 | 0.92 | MMP13 (0.65) | MMP13ADAMTS4MMP3MMP8MMP12 | |
| SCHEMBL5428067 | 0.92 | MMP13 (0.65) | MMP13ADAMTS4MMP3MMP8MMP12 | |
| SCHEMBL5431521 | 0.92 | MMP13 (0.65) | MMP13ADAMTS4MMP3MMP8MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038284-A2 | HETEROBICYLIC METALLOPROTEASE INHIBITORS | Alantos Pharmaceuticals, Inc. (US) | 2009-03-25 | — | — | EP | disclosed |
| WO-2007139860-A2 | HETEROBICYLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS, INC. (US) | 2007-12-06 | — | — | WO | disclosed |