Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4222550 | 1.00 | HSD11B1 (0.44) | HSD11B1NPC1ALDH1A1IKBKBEGFR | |
| SCHEMBL4227874 | 0.90 | CYP2C9 (0.45) | HSD11B1NPC1EGFRMAPTSMN1; SMN2 | |
| SCHEMBL4227868 | 0.90 | CYP2C9 (0.45) | HSD11B1NPC1EGFRMAPTSMN1; SMN2 | |
| SCHEMBL4227068 | 0.89 | CYP1A2 (0.35) | HSD11B1NPC1ACHEMAPTSMN1; SMN2 | |
| SCHEMBL4237370 | 0.89 | EGFR (0.38) | HSD11B1NPC1EGFRMAPTSMN1; SMN2 | |
| SCHEMBL4227860 | 0.89 | AKR1C3 (0.40) | HSD11B1NPC1ALDH1A1EGFRACHE | |
| SCHEMBL4227066 | 0.89 | CYP1A2 (0.35) | HSD11B1NPC1ACHEMAPTSMN1; SMN2 | |
| SCHEMBL4227862 | 0.89 | AKR1C3 (0.40) | HSD11B1NPC1ALDH1A1EGFRACHE | |
| SCHEMBL4237365 | 0.89 | EGFR (0.38) | HSD11B1NPC1EGFRMAPTSMN1; SMN2 | |
| SCHEMBL4543260 | 0.88 | CYP1A2 (0.41) | NPC1ALDH1A1EGFRACHEMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090062401-A1 | DECALINE-DERIVED COMPOUNDS AS PHARMACEUTICALLY ACTIVE AGENTS | UNIVERSITAT DORTMUND (DE) | 2009-03-05 | — | — | US | claimed |
| EP-1841723-A1 | DECALINE DERIVED COMPOUNDS AS PHARMACEUTICALLY ACTIVE AGENTS | Universität Dortmund (DE) | 2007-10-10 | — | — | EP | claimed |
| WO-2006069787-A1 | DECALINE-DERIVED COMPOUNDS AS PHARMACEUTICALLY ACTIVE AGENTS | Universität Dortmund (DE) | 2006-07-06 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062401-A1 | DECALINE-DERIVED COMPOUNDS AS PHARMACEUTICALLY ACTIVE AGENTS | CHAT, DLAT, CPT1A | HSD11B1 43/4885NPC1 584/4885ALDH1A1 1533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.