Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 10/20 | 0.71 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 2/20 | 0.38 |
| ▸ | STAT3 | P40763 | 4/20 | 0.38 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5941389 | 1.00 | CTSK (0.71) | CTSKCTSSACESTAT3CAPN1 | |
| SCHEMBL4044347 | 1.00 | CTSK (0.71) | CTSKCTSSACESTAT3CAPN1 | |
| SCHEMBL4217216 | 1.00 | CTSK (0.71) | CTSKCTSSACESTAT3CAPN1 | |
| SCHEMBL4042741 | 0.98 | CTSK (0.70) | CTSKCTSSACESTAT3CAPN1 | |
| SCHEMBL4045507 | 0.92 | CTSK (0.60) | CTSKCTSSACESTAT3CAPN1 | |
| SCHEMBL4364104 | 0.91 | CTSK (0.82) | CTSKCTSSKMT2ACTSBCCR1 | |
| SCHEMBL4364108 | 0.91 | CTSK (0.82) | CTSKCTSSKMT2ACTSBCCR1 | |
| SCHEMBL4364101 | 0.91 | CTSK (0.82) | CTSKCTSSKMT2ACTSBCCR1 | |
| SCHEMBL5941936 | 0.91 | CTSK (0.82) | CTSKCTSSKMT2ACTSBCCR1 | |
| SCHEMBL4042535 | 0.90 | CTSK (0.58) | CTSKCTSSACESTAT3CAPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051974-A1 | TETRAHYDROBENZOTHIOPHENE DERIVATIVES | 4SC AG (DE) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008020045-A1 | TETRAHYDROBENZOTHIOPHENE DERIVATIVES | 4SC AG (DE) | 2008-02-21 | — | — | WO | disclosed |