Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UGCG | Q16739 | 5/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | BCR | P11274 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | RBP4 | P02753 | 2/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4261851 | 0.92 | DYRK1A (0.43) | UGCGGSK3BDYRK1A | |
| SCHEMBL1572745 | 0.86 | GSK3B (0.43) | UGCGABL1BCRGSK3BDYRK1A | |
| SCHEMBL1572482 | 0.84 | CDK2 (0.52) | GSK3BRBP4CHRNA7CDK2GSK3A | |
| SCHEMBL1572497 | 0.82 | HAO1 (0.39) | UGCGABL1BCRGSK3BDYRK1A | |
| SCHEMBL12715360 | 0.80 | CHRNA7 (0.41) | UGCGGSK3BRBP4CHRNA7CDK2 | |
| SCHEMBL1636591 | 0.80 | USP30 (0.36) | UGCGABL1BCRDYRK1ARBP4 | |
| SCHEMBL1572454 | 0.80 | CHEK1 (0.40) | UGCGABL1BCRGSK3BCHRNA7 | |
| SCHEMBL12715304 | 0.79 | UGCG (0.51) | UGCGGSK3BRBP4CHRNA7 | |
| SCHEMBL1573168 | 0.79 | UGCG (0.51) | UGCGGSK3BRBP4CHRNA7 | |
| Bromide SCHEMBL3862357 | 0.79 | MAPT (0.41) | UGCGABL1BCRRBP4CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8524706-B2 | 1,4-diazabicyclo[3.2.2]nonanecarboxamide derivatives, preparation and therapeutic use thereof | SANOFI (FR) | 2013-09-03 | — | — | US | disclosed |
| US-20090054416-A1 | 1,4-Diazabicyclo[3.2.2]nonanecarboxamide Derivatives, Preparation and Therapeutic Use Thereof | SANOFI-AVENTIS (FR) | 2009-02-26 | — | — | US | disclosed |
| US-7456171-B2 | 1,4-Diazabicyclo[3.2.2]nonanecarboxamide derivatives, preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2008-11-25 | — | — | US | disclosed |
| US-20050182062-A1 | 1,4-Diazabicyclo[3.2.2]nonanecarboxamide derivatives, preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2005-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054416-A1 | 1,4-Diazabicyclo[3.2.2]nonanecarboxamide Derivatives, Preparation and Therapeutic Use Thereof | CNR1, CNR2, CACNA1A | UGCG 1634/4885ABL1 1975/4885BCR 2112/4885 |
| US-20050182062-A1 | 1,4-Diazabicyclo[3.2.2]nonanecarboxamide derivatives, preparation and therapeutic use thereof | CNR1, CNR2, CBR3 | UGCG 2490/4885ABL1 946/4885BCR 1408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.