Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 2/20 | 0.51 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | AHR | P35869 | 1/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.51 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 11/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | IGF1R | P08069 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4224401 | 0.91 | GSK3A (0.52) | GSK3AGSK3BNR1I2AHRCDK5 | |
| SCHEMBL1751684 | 0.91 | GSK3A (0.51) | GSK3AGSK3BNR1I2AHRCDK5 | |
| SCHEMBL656365 | 0.90 | POLB (0.51) | CDK5CDK5R1MAPTTDP1IGF1R | |
| SCHEMBL1748903 | 0.86 | GSK3A (0.53) | GSK3AGSK3BNR1I2AHRCDK5 | |
| SCHEMBL1751472 | 0.84 | IGF1R (0.53) | GSK3AGSK3BNR1I2AHRCDK5 | |
| SCHEMBL28757222 | 0.82 | MAPT (0.52) | GSK3AGSK3BCDK5CDK5R1MAPT | |
| SCHEMBL4052739 | 0.80 | IGF1R (0.51) | GSK3AGSK3BNR1I2AHRCDK5 | |
| SCHEMBL4227109 | 0.80 | IGF1R (0.51) | GSK3AGSK3BNR1I2AHRCDK5 | |
| SCHEMBL4052746 | 0.80 | IGF1R (0.51) | GSK3AGSK3BNR1I2AHRCDK5 | |
| SCHEMBL4221102 | 0.77 | CDC25B (0.43) | GSK3AGSK3BNR1I2AHRCDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078018-A1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | Signal Pharmaceuticals LLC (US) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008051494-A1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-05-02 | — | — | WO | disclosed |