Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 2/20 | 0.52 |
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.52 |
| ▸ | AHR | P35869 | 1/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.52 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 10/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | AURKA | O14965 | 3/20 | 0.50 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1748903 | 0.91 | GSK3A (0.53) | GSK3AGSK3BPOLBNR1I2AHR | |
| SCHEMBL4223368 | 0.91 | GSK3A (0.51) | GSK3AGSK3BPOLBNR1I2AHR | |
| SCHEMBL1751472 | 0.86 | IGF1R (0.53) | GSK3AGSK3BPOLBNR1I2AHR | |
| SCHEMBL1751684 | 0.85 | GSK3A (0.51) | GSK3AGSK3BPOLBNR1I2AHR | |
| SCHEMBL4052739 | 0.81 | IGF1R (0.51) | GSK3AGSK3BPOLBNR1I2AHR | |
| SCHEMBL4227109 | 0.81 | IGF1R (0.51) | GSK3AGSK3BPOLBNR1I2AHR | |
| SCHEMBL4052746 | 0.81 | IGF1R (0.51) | GSK3AGSK3BPOLBNR1I2AHR | |
| SCHEMBL656365 | 0.80 | POLB (0.51) | POLBCDK5CDK5R1MAPTTDP1 | |
| SCHEMBL4566417 | 0.76 | GSK3A (0.45) | GSK3AGSK3BPOLBNR1I2AHR | |
| SCHEMBL656643 | 0.75 | MAPT (0.50) | POLBMAPTTDP1IGF1RKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078018-A1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | Signal Pharmaceuticals LLC (US) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008051494-A1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-05-02 | — | — | WO | disclosed |