Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.49 |
| ▸ | ACP1 | P24666 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8257613 | 0.83 | HSP90AB1 (0.62) | HSP90AB1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8360725 | 0.83 | HSP90AB1 (0.62) | HSP90AB1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4210969 | 0.82 | CYP1A2 (0.45) | ACP1ALOX5MEN1KMT2AALDH1A1 | |
| SCHEMBL31458970 | 0.81 | HSP90AB1 (0.49) | HSP90AB1PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL1997562 | 0.81 | HSP90AB1 (0.49) | HSP90AB1PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL1571230 | 0.78 | PTGS2 (0.54) | ACP1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL5748815 | 0.78 | HSP90AB1 (0.45) | HSP90AB1PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL30673283 | 0.77 | ACP1 (0.42) | ACP1ALOX5MEN1KMT2AALDH1A1 | |
| SCHEMBL27725733 | 0.77 | HSP90AB1 (0.76) | HSP90AB1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL2015555 | 0.77 | ACP1 (0.42) | ACP1ALOX5MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090143396-A1 | Sulfonyl-Substituted Aryl Compounds as Modulators of Peroxisome Proliferator Activated Receptors | MALECHA JAMES W | 2009-06-04 | — | — | US | disclosed |
| CN-101374813-A | Arylsulfonamide and sulfonyl compounds as PPAR modulators and methods of treating metabolic disorders | KALYPSYS INC (US) | 2009-02-25 | — | — | CN | disclosed |
| WO-2007047431-A2 | SULFONYL-SUBSTITUTED ARYL COMPOUNDS AS MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS | KALYPSYS, INC. (US) | 2007-04-26 | — | — | WO | disclosed |
| EP-1735280-A1 | ARYL SULFONAMIDE AND SULFONYL COMPOUNDS AS MODULATORS OF PPAR AND METHODS OF TREATING METABOLIC DISORDERS | Kalypsys, Inc. (US) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005115983-A1 | ARYL SULFONAMIDE AND SULFONYL COMPOUNDS AS MODULATORS OF PPAR AND METHODS OF TREATING METABOLIC DISORDERS | KALYPSYS, INC. (US) | 2005-12-08 | — | — | WO | disclosed |
| US-20050234046-A1 | Aryl sulfonamide and sulfonyl compounds as modulators of PPAR and methods of treating metabolic disorders | KALYPSYS, INC. (US) | 2005-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143396-A1 | Sulfonyl-Substituted Aryl Compounds as Modulators of Peroxisome Proliferator Activated Receptors | PPARG, PPARA, PPARD | HSP90AB1 1201/4885ACP1 2446/4885ALOX5 1049/4885 |
| US-20050234046-A1 | Aryl sulfonamide and sulfonyl compounds as modulators of PPAR and methods of treating metabolic disorders | PPARA, PPARG, PPARD | HSP90AB1 1152/4885ACP1 2687/4885ALOX5 1120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.