Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.57 |
| ▸ | HTR2C | P28335 | 6/20 | 0.57 |
| ▸ | HTR2B | P41595 | 6/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.57 |
| ▸ | DRD2 | P14416 | 5/20 | 0.57 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.51 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.47 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.47 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.47 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.47 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.47 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4223594 | 1.00 | HTR2A (0.57) | HTR2AHTR2CHTR2BSIGMAR1DRD2 | |
| SCHEMBL4864890 | 0.90 | SIGMAR1 (0.49) | HTR2AHTR2CHTR2BSIGMAR1DRD2 | |
| SCHEMBL4864879 | 0.90 | SIGMAR1 (0.49) | HTR2AHTR2CHTR2BSIGMAR1DRD2 | |
| Hydrochloric Acid SCHEMBL4234165 | 0.90 | HTR2A (0.56) | HTR2AHTR2CHTR2BSIGMAR1DRD2 | |
| Hydrochloric Acid SCHEMBL4234154 | 0.90 | HTR2A (0.56) | HTR2AHTR2CHTR2BSIGMAR1DRD2 | |
| SCHEMBL4221451 | 0.88 | HTR2A (0.56) | HTR2AHTR2CHTR2BSIGMAR1DRD2 | |
| SCHEMBL4218578 | 0.88 | HTR2A (0.56) | HTR2AHTR2CHTR2BSIGMAR1DRD2 | |
| SCHEMBL4221456 | 0.88 | HTR2A (0.56) | HTR2AHTR2CHTR2BSIGMAR1DRD2 | |
| SCHEMBL4219112 | 0.88 | HTR2A (0.56) | HTR2AHTR2CHTR2BSIGMAR1DRD2 | |
| SCHEMBL4218586 | 0.88 | HTR2A (0.56) | HTR2AHTR2CHTR2BSIGMAR1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7557127-B2 | HDAC inhibitor | ASTELLAS PHARMA INC. (JP) | 2009-07-07 | — | — | US | disclosed |
| US-20090054464-A1 | HDAC INHIBITOR | ASTELLAS PHARMA INC. (JP) | 2009-02-26 | — | — | US | disclosed |
| US-7465731-B2 | HDAC inhibitor | ASTELLAS PHARMA INC. (JP) | 2008-12-16 | — | — | US | disclosed |
| EP-1776357-A1 | HYDROXYAMIDE COMPOUNDS HAVING ACTIVITY AS INHIBITORS OF HISTONE DEACETYLASE (HDAC) | Astellas Pharma Inc. (JP) | 2007-04-25 | — | — | EP | disclosed |
| US-20060052599-A1 | HDAC inhibitor | ASTELLAS PHARMA INC. (JP) | 2006-03-09 | — | — | US | disclosed |
| WO-2006016680-A1 | HYDROXYAMIDE COMPOUNDS HAVING ACTIVITY AS INHIBITORS OF HISTONE DEACETYLASE (HDAC) | ASTELLAS PHARMA INC. (JP) | 2006-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060052599-A1 | HDAC inhibitor | HDAC1, HDAC2, HDAC11 | HTR2A 621/4885HTR2C 1291/4885HTR2B 692/4885 |
| US-20090054464-A1 | HDAC INHIBITOR | HDAC1, HDAC2, HDAC8 | HTR2A 436/4885HTR2C 847/4885HTR2B 509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.