Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.65 |
| ▸ | CTSS | P25774 | 1/20 | 0.49 |
| ▸ | MC4R | P32245 | 2/20 | 0.44 |
| ▸ | MC3R | P41968 | 2/20 | 0.44 |
| ▸ | MC1R | Q01726 | 2/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | GPR132 | Q9UNW8 | 2/20 | 0.39 |
| ▸ | PREP | P48147 | 2/20 | 0.39 |
| ▸ | FAP | Q12884 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8348784 | 1.00 | CTSK (0.65) | CTSKCTSSMC4RMC3RMC1R | |
| SCHEMBL4223839 | 1.00 | CTSK (0.65) | CTSKCTSSMC4RMC3RMC1R | |
| SCHEMBL4223836 | 1.00 | CTSK (0.65) | CTSKCTSSMC4RMC3RMC1R | |
| SCHEMBL5942278 | 0.93 | CTSK (0.65) | CTSKCTSSMC4RMC3RMC1R | |
| SCHEMBL5942280 | 0.93 | CTSK (0.65) | CTSKCTSSMC4RMC3RMC1R | |
| SCHEMBL5941548 | 0.91 | CTSK (0.66) | CTSKCTSSMC4RMC3RMC1R | |
| SCHEMBL5941551 | 0.91 | CTSK (0.66) | CTSKCTSSMC4RMC3RMC1R | |
| SCHEMBL4046339 | 0.90 | CTSK (0.55) | CTSKCTSSMC4RMC3RMC1R | |
| SCHEMBL5941468 | 0.89 | CTSK (0.82) | CTSKCTSSPREPFAPRAB9A | |
| SCHEMBL4041237 | 0.89 | CTSK (0.82) | CTSKCTSSPREPFAPRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | disclosed |