Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKN1 | Q16512 | 1/20 | 0.52 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.52 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.51 |
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.51 |
| ▸ | SIRT1 | Q96EB6 | 4/20 | 0.51 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13735109 | 0.88 | MAPT (0.55) | PKN1PKN2HCRTR1SIRT2SIRT1 | |
| SCHEMBL11118850 | 0.85 | MAPT (0.58) | HCRTR1MAPTTP53ALDH1A1RAB9A | |
| SCHEMBL6169066 | 0.83 | HCRTR1 (0.56) | PKN1PKN2HCRTR1SIRT2SIRT1 | |
| SCHEMBL11148656 | 0.81 | HCRTR1 (0.53) | PKN1PKN2HCRTR1SIRT2SIRT1 | |
| SCHEMBL7795891 | 0.81 | HCRTR1 (0.53) | PKN1PKN2HCRTR1SIRT2SIRT1 | |
| SCHEMBL11824061 | 0.81 | SIRT2 (0.56) | PKN1PKN2HCRTR1SIRT2SIRT1 | |
| SCHEMBL24966452 | 0.80 | SMN1; SMN2 (0.46) | MAPTALDH1A1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL12393006 | 0.80 | HRH3 (0.56) | PKN1PKN2HCRTR1SIRT2SIRT1 | |
| SCHEMBL14473811 | 0.80 | ALDH1A1 (0.53) | PKN1PKN2HCRTR1SIRT2SIRT1 | |
| SCHEMBL12393020 | 0.80 | ALDH1A1 (0.54) | PKN1PKN2HCRTR1SIRT2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078018-A1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | Signal Pharmaceuticals LLC (US) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008051494-A1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-05-02 | — | — | WO | disclosed |