Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | DRD3 | P35462 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4224541 | 1.00 | NPC1 (0.46) | NPC1RAB9ATNKSDRD2DRD3 | |
| SCHEMBL872540 | 0.94 | NPC1 (0.46) | NPC1RAB9ATNKSDRD2DRD3 | |
| SCHEMBL872539 | 0.94 | NPC1 (0.46) | NPC1RAB9ATNKSDRD2DRD3 | |
| SCHEMBL871133 | 0.92 | NPC1 (0.49) | NPC1RAB9ATNKSDRD2DRD3 | |
| SCHEMBL871132 | 0.92 | NPC1 (0.49) | NPC1RAB9ATNKSDRD2DRD3 | |
| SCHEMBL871515 | 0.91 | RAB9A (0.54) | NPC1RAB9ATNKSKDM4ESMN1; SMN2 | |
| SCHEMBL871516 | 0.91 | RAB9A (0.54) | NPC1RAB9ATNKSKDM4ESMN1; SMN2 | |
| SCHEMBL10221672 | 0.91 | NPC1 (0.42) | NPC1RAB9ATNKSDRD2DRD3 | |
| SCHEMBL871249 | 0.90 | NPC1 (0.41) | NPC1RAB9ATNKSDRD2DRD3 | |
| SCHEMBL871248 | 0.90 | NPC1 (0.41) | NPC1RAB9ATNKSDRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090124596-A1 | Chemical Compounds 637 | ALCON RESEARCH, LTD. | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124596-A1 | Chemical Compounds 637 | PDE4A, PDE4B, PDE3B | NPC1 2462/4885RAB9A 1736/4885TNKS 1921/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.