Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.36 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.33 |
| ▸ | CA7 | P43166 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.32 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.32 |
| ▸ | KDM6B | O15054 | 2/20 | 0.32 |
| ▸ | KDM5C | P41229 | 2/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1626498 | 0.90 | HDAC6 (0.40) | HDAC6HDAC1HDAC2CA14NAALAD2 | |
| SCHEMBL20319924 | 0.81 | CA14 (0.42) | HDAC6HDAC1HDAC2CA14CA1 | |
| SCHEMBL28378832 | 0.81 | HDAC6 (0.39) | HDAC6HDAC1HDAC2CA14CA1 | |
| SCHEMBL18281227 | 0.79 | HDAC6 (0.41) | HDAC6HDAC1HDAC2CA14LMNA | |
| SCHEMBL2499626 | 0.79 | CA14 (0.50) | HDAC6HDAC1HDAC2CA14NAALAD2 | |
| SCHEMBL4888113 | 0.78 | HDAC1 (0.44) | HDAC6HDAC1HDAC2CA14LMNA | |
| SCHEMBL9426075 | 0.77 | CA1 (0.35) | HDAC6HDAC1HDAC2CA14NAALAD2 | |
| SCHEMBL2580993 | 0.77 | CA14 (0.49) | HDAC6HDAC1HDAC2CA14NAALAD2 | |
| SCHEMBL381146 | 0.77 | HDAC6 (0.39) | HDAC6HDAC1HDAC2CA14NAALAD2 | |
| SCHEMBL2194683 | 0.76 | HDAC1 (0.46) | HDAC6HDAC1HDAC2CA14LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8354418-B2 | Thiazolyl-dihydro-quinazolines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-01-15 | — | — | US | disclosed |
| US-20090131424-A1 | THIAZOLYL-DIHYDRO-CHINAZOLINE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-05-21 | — | — | US | disclosed |
| US-20070238746-A1 | THIAZOLYL-DIHYDRO-CHINAZOLINE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070238746-A1 | THIAZOLYL-DIHYDRO-CHINAZOLINE | CYP3A7, UGT2B7, UGT1A7 | HDAC6 607/4885HDAC1 1200/4885HDAC2 1556/4885 |
| US-20090131424-A1 | THIAZOLYL-DIHYDRO-CHINAZOLINE | CYP3A7, UGT2B7, UGT1A7 | HDAC6 607/4885HDAC1 1200/4885HDAC2 1556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.