Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 5/20 | 0.80 |
| ▸ | ESR1 | P03372 | 1/20 | 0.80 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.80 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.80 |
| ▸ | AKT1 | P31749 | 1/20 | 0.74 |
| ▸ | KDM1A | O60341 | 2/20 | 0.69 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.69 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.66 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.66 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.66 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.66 |
| ▸ | PARP1 | P09874 | 3/20 | 0.60 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.60 |
| ▸ | APP | P05067 | 1/20 | 0.57 |
| ▸ | MAOB | P27338 | 2/20 | 0.56 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29808504 | 0.89 | PDE4D (1.00) | PDE5AESR1PDE4DESR2AKT1 | |
| SCHEMBL1231403 | 0.89 | PDE4D (1.00) | PDE5AESR1PDE4DESR2AKT1 | |
| SCHEMBL19354056 | 0.88 | PDE5A (0.61) | PDE5AESR1PDE4DESR2AKT1 | |
| SCHEMBL20045159 | 0.87 | DYRK1A (0.84) | PDE5AESR1PDE4DESR2AKT1 | |
| SCHEMBL3192507 | 0.87 | PDE5A (0.83) | PDE5AESR1PDE4DESR2AKT1 | |
| SCHEMBL20954090 | 0.86 | PDE5A (0.83) | PDE5AESR1PDE4DESR2AKT1 | |
| SCHEMBL4828372 | 0.85 | AKT1 (1.00) | PDE5AESR1PDE4DESR2AKT1 | |
| SCHEMBL19353997 | 0.85 | PARP1 (0.65) | PDE5AESR1PDE4DESR2KDM1A | |
| SCHEMBL28950297 | 0.85 | SLC22A2 (0.72) | PDE5AESR1PDE4DESR2AKT1 | |
| SCHEMBL20045166 | 0.85 | DYRK1A (0.71) | PDE5AESR1PDE4DESR2AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017156520-A1 | ICARIIN AND ICARITIN DERIVATIVES | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2017-09-14 | — | — | WO | disclosed |
| US-8252835-B2 | 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)-4H-chromen-4-one; for modulating functions of estrogen receptor alpha 36, preventing or treating diseases related to estrogen receptor alpha 36, such as asthma, for inducing cell death or inhibiting cell proliferation | SHENOGEN PHARMA GROUP LTD. (CN) | 2012-08-28 | — | — | US | disclosed |
| EP-2096916-A2 | COMPOUNDS AND METHODS FOR TREATING ESTROGEN RECEPTOR-RELATED DISEASES | Shenogen Pharma Group Ltd. (CN) | 2009-09-09 | — | — | EP | disclosed |
| US-20080146658-A1 | COMPOUNDS AND METHODS FOR TREATING ESTROGEN RECEPTOR-RELATED DISEASES | SHENOGEN PHARMA GROUP LTD. (CN) | 2008-06-19 | — | — | US | disclosed |
| WO-2008052005-A2 | COMPOUNDS AND METHODS FOR TREATING ESTROGEN RECEPTOR-RELATED DISEASES | SHENOGEN PHARMA GROUP LTD. (CN) | 2008-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146658-A1 | COMPOUNDS AND METHODS FOR TREATING ESTROGEN RECEPTOR-RELATED DISEASES | GPER1, ESR1, ESR2 | PDE5A 3581/4885ESR1 2/4885PDE4D 4010/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.