SCHEMBL4228646

SCHEMBL4228646

CC(C)N1CCC(Oc2ccc(C(=O)O)cc2)CC1

nearest known ligand 0.70

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 19/20 0.70
SRD5A1 P18405 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4239131 0.92 HRH3 (0.62) HRH3SRD5A1
SCHEMBL4925740 0.88 HRH3 (0.70) HRH3
SCHEMBL4501705 0.88 HRH3 (0.74) HRH3
SCHEMBL5207659 0.87 HRH3 (0.65) HRH3
SCHEMBL23497366 0.85 ALDH1A1 (0.55) HRH3SRD5A1
SCHEMBL2927433 0.85 HRH3 (0.53) HRH3SRD5A1
SCHEMBL2927436 0.85 HRH3 (0.53) HRH3SRD5A1
SCHEMBL4237314 0.83 HRH3 (0.57) HRH3
SCHEMBL4236787 0.83 HRH3 (0.54) HRH3SRD5A1
SCHEMBL3458790 0.83 SRD5A1 (0.59) HRH3SRD5A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090233910-A1 Npy antagonists, preparation and uses CEREP (FR) 2009-09-17 US disclosed
US-20090233910-A1 Npy antagonists, preparation and uses CEREP (FR) 2009-09-17 US disclosed
US-20090233910-A1 Npy antagonists, preparation and uses CEREP (FR) 2009-09-17 US disclosed
EP-1879887-A2 NPY ANTAGONISTS, PREPARATION AND USE Cerep (FR) 2008-01-23 EP disclosed
WO-2006108965-A2 NPY ANTAGONISTS, PREPARATION AND USE CEREP (FR) 2006-10-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090233910-A1 Npy antagonists, preparation and uses NPY1R, NPY5R, NPY2R HRH3 210/4885SRD5A1 2198/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.