Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 3/20 | 0.63 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4055836 | 0.85 | MTOR (0.65) | MTORPIK3CAPIK3CDPIK3CG | |
| SCHEMBL4052381 | 0.83 | MTOR (0.86) | MTORPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL4058302 | 0.80 | MTOR (0.84) | MTORPIK3CAPIK3R1 | |
| SCHEMBL4057364 | 0.80 | MTOR (0.72) | MTORPIK3CALMNACYP1A2CYP3A4 | |
| SCHEMBL4057172 | 0.80 | MTOR (0.79) | MTORPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL4050757 | 0.80 | MTOR (0.79) | MTORPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL4053948 | 0.79 | MTOR (0.84) | MTORPIK3CAPIK3R1 | |
| SCHEMBL4051833 | 0.79 | PIK3CA (0.57) | MTORPIK3CAPIK3CDPIK3CG | |
| SCHEMBL4053032 | 0.78 | MTOR (0.65) | MTORPIK3CALMNACYP1A2CYP3A4 | |
| SCHEMBL4057856 | 0.78 | MTOR (0.64) | MTORPIK3CALMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111547-A1 | 7H-PYRROLO[2,3-H]QUINAZOLINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH (US) | 2009-09-11 | — | — | WO | claimed |