Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 18/20 | 0.70 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | DHFR | P00374 | 1/20 | 0.55 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23590311 | 0.91 | DHODH (0.65) | DHODHPDE10ATSHRDHFRALKBH5 | |
| SCHEMBL29617670 | 0.91 | DHODH (0.65) | DHODHPDE10ATSHRDHFRALKBH5 | |
| SCHEMBL28170815 | 0.86 | DHODH (0.73) | DHODHPDE10ATSHRGAA | |
| SCHEMBL29617658 | 0.84 | DHODH (0.66) | DHODHPDE10ADHFRALKBH5 | |
| SCHEMBL23590313 | 0.84 | DHODH (0.66) | DHODHPDE10ADHFRALKBH5 | |
| SCHEMBL4229394 | 0.83 | TACR3 (0.52) | DHODHPDE10ATSHR | |
| SCHEMBL28170272 | 0.83 | DHODH (0.65) | DHODHPDE10ATSHRGAA | |
| SCHEMBL28170814 | 0.82 | DHODH (0.68) | DHODHPDE10ATSHRGAA | |
| SCHEMBL5908779 | 0.81 | DHODH (0.47) | DHODHPDE10ATSHRGAA | |
| SCHEMBL28170812 | 0.81 | DHODH (0.67) | DHODHPDE10ATSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054440-A1 | Quinoline derivatives as neurokinin receptor antagonists | CARLING WILLIAM ROBERT | 2009-02-26 | — | — | US | disclosed |
| EP-1888530-A2 | QUINOLINE DERIVATIVES AS NEUROKININ RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006120478-A2 | QUINOLINE DERIVATIVES AS NEUROKININ RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 2006-11-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054440-A1 | Quinoline derivatives as neurokinin receptor antagonists | TACR2, TACR3, NPY2R | DHODH 3852/4885PDE10A 2016/4885TSHR 400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.