Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 18/20 | 0.65 |
| ▸ | DHFR | P00374 | 1/20 | 0.58 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.58 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23590311 | 1.00 | DHODH (0.65) | DHODHDHFRALKBH5PDE10ATSHR | |
| SCHEMBL4228780 | 0.91 | DHODH (0.70) | DHODHDHFRALKBH5PDE10ATSHR | |
| SCHEMBL29617658 | 0.88 | DHODH (0.66) | DHODHDHFRALKBH5PDE10A | |
| SCHEMBL23590313 | 0.88 | DHODH (0.66) | DHODHDHFRALKBH5PDE10A | |
| SCHEMBL29617666 | 0.77 | DHODH (0.90) | DHODHDHFRALKBH5PDE10A | |
| SCHEMBL23590030 | 0.77 | DHODH (0.90) | DHODHDHFRALKBH5PDE10A | |
| SCHEMBL28170815 | 0.77 | DHODH (0.73) | DHODHPDE10ATSHR | |
| SCHEMBL8732559 | 0.75 | DHODH (1.00) | DHODHDHFRALKBH5 | |
| SCHEMBL4229394 | 0.75 | TACR3 (0.52) | DHODHPDE10ATSHRTP53 | |
| SCHEMBL28170272 | 0.74 | DHODH (0.65) | DHODHPDE10ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240294477-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE | OHIO STATE INNOVATION FOUNDATION (US) | 2024-09-05 | — | — | US | disclosed |
| US-11999697-B2 | Methods and compositions for inhibition of dihydroorotate dehydrogenase | OHIO STATE INNOVATION FOUNDATION (US) | 2024-06-04 | — | — | US | disclosed |
| US-11312686-B2 | Methods and compositions for inhibition of dihydroorotate dehydrogenase | OHIO STATE INNOVATION FOUNDATION (US) | 2022-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11312686-B2 | Methods and compositions for inhibition of dihydroorotate dehydrogenase | DHODH, DLD, DPYD | DHODH 1/4885DHFR 5/4885ALKBH5 668/4885 |
| US-20240294477-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE | DHODH, DLD, DPYD | DHODH 1/4885DHFR 5/4885ALKBH5 672/4885 |
| US-11999697-B2 | Methods and compositions for inhibition of dihydroorotate dehydrogenase | DHODH, DLD, DPYD | DHODH 1/4885DHFR 5/4885ALKBH5 672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.