Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 12/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 12/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 6/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 6/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | DRD5 | P21918 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2383746 | 0.94 | HDAC1 (0.47) | HDAC3HDAC1HDAC8HDAC2NCOR2 | |
| SCHEMBL2385454 | 0.92 | UTS2R (0.45) | HDAC3HDAC1HDAC8HDAC2NCOR2 | |
| SCHEMBL4224033 | 0.91 | HDAC1 (0.51) | HDAC3HDAC1HDAC8HDAC2NCOR2 | |
| SCHEMBL4223952 | 0.90 | HDAC1 (0.46) | HDAC3HDAC1HDAC8HDAC2NCOR2 | |
| SCHEMBL4219358 | 0.90 | HDAC3 (0.46) | HDAC3HDAC1HDAC8HDAC2NCOR2 | |
| SCHEMBL2385536 | 0.89 | HDAC3 (0.43) | HDAC3HDAC1HDAC8HDAC2NCOR2 | |
| SCHEMBL4228901 | 0.89 | HDAC1 (0.47) | HDAC3HDAC1HDAC8HDAC2NCOR2 | |
| SCHEMBL3234270 | 0.88 | TMEM97 (0.38) | HDAC3HDAC1HDAC2NCOR2TMEM97 | |
| SCHEMBL4229378 | 0.87 | HDAC1 (0.48) | HDAC3HDAC1HDAC8HDAC2NCOR2 | |
| SCHEMBL2386741 | 0.86 | HDAC3 (0.43) | HDAC3HDAC1HDAC8HDAC2NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2133339-A1 | NOVEL (2-AMINOPHENYL)PYRIDINECARBOXAMIDE DERIVATIVE HAVING UREA STRUCTURE | Santen Pharmaceutical Co., Ltd (JP) | 2009-12-16 | — | — | EP | disclosed |