Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4234298 | 0.92 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL4233567 | 0.87 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL27789328 | 0.87 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL4232766 | 0.85 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL1703381 | 0.84 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL4229400 | 0.80 | POLB (0.51) | ALDH1A1SMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL4234481 | 0.79 | PDE10A (0.45) | ALDH1A1SMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL4961253 | 0.78 | PDE4A (0.56) | ALDH1A1SMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL4229663 | 0.77 | USP2 (0.53) | ALDH1A1SMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL4238926 | 0.77 | PDE4B (0.42) | ALDH1A1SMN1; SMN2RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097422-A1 | THIENOPYRIMIDINONES FOR TREATMENT OF INFLAMMATORY DISORDERS AND CANCERS | Eli Lilly & Co. (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008064018-A1 | THIENOPYRIMIDINONES FOR TREATMENT OF INFLAMMATORY DISORDERS AND CANCERS | ELI LILLY & CO. (US) | 2008-05-29 | — | — | WO | disclosed |