Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 1/20 | 0.53 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.39 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 4/20 | 0.38 |
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 2/20 | 0.36 |
| ▸ | CTSB | P07858 | 2/20 | 0.36 |
| ▸ | CTSS | P25774 | 2/20 | 0.36 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3771840 | 0.94 | SSTR5 (0.58) | SSTR5KDM1AEHMT2RCOR1ACHE | |
| SCHEMBL4227836 | 0.89 | SSTR5 (0.54) | SSTR5KDM1AEHMT2RCOR1ACHE | |
| SCHEMBL4224514 | 0.87 | SSTR5 (0.45) | SSTR5KDM1AEHMT2RCOR1ACHE | |
| SCHEMBL3772004 | 0.87 | SSTR5 (0.52) | SSTR5KDM1AEHMT2RCOR1ACHE | |
| SCHEMBL4240279 | 0.83 | SSTR5 (0.50) | SSTR5ACHEBACE1ALDH1A1ROCK2 | |
| SCHEMBL3782984 | 0.82 | SSTR5 (0.59) | SSTR5KDM1AEHMT2RCOR1ACHE | |
| SCHEMBL4222888 | 0.81 | EHMT2 (0.49) | SSTR5KDM1AEHMT2RCOR1NSD2 | |
| SCHEMBL4225976 | 0.80 | SSTR5 (0.54) | SSTR5ACHEBACE1SIGMAR1NSD2 | |
| SCHEMBL1748288 | 0.80 | SSTR5 (0.53) | SSTR5ACHEBACE1ALDH1A1MCHR1 | |
| SCHEMBL3775060 | 0.80 | SSTR5 (0.49) | SSTR5KDM1AEHMT2RCOR1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001867-B1 | PYRIMIDINE, QUINAZOLINE, PTERIDINE AND TRIAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2009-07-01 | — | — | EP | disclosed |