Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 9/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PPARD | Q03181 | 2/20 | 0.44 |
| ▸ | HTR6 | P50406 | 4/20 | 0.44 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | FABP2 | P12104 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6085083 | 0.81 | HTR6 (0.44) | KDM4EMAPTKMT2AHTR6 | |
| SCHEMBL6087229 | 0.79 | HTR2C (0.56) | ALDH1A1KDM4EMAPTHTR6 | |
| SCHEMBL6192715 | 0.75 | CNR2 (0.44) | ALDH1A1KDM4EMAPTHTR6MAPK1 | |
| SCHEMBL4239918 | 0.75 | PPARA (0.57) | PPARAALDH1A1KDM4EHSD17B10PLA2G2A | |
| SCHEMBL6190327 | 0.75 | CNR2 (0.50) | ALDH1A1KDM4EMEN1CYP1A2MAPT | |
| SCHEMBL6085436 | 0.74 | HTR6 (0.60) | PPARAPPARGPPARDHTR6 | |
| SCHEMBL6192840 | 0.74 | POLB (0.53) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL6086045 | 0.73 | KMT2A (0.48) | ALDH1A1KDM4EMAPTKMT2A | |
| SCHEMBL9056875 | 0.73 | HTR6 (0.55) | HTR6MAPK1L3MBTL1BCHE | |
| SCHEMBL8389282 | 0.71 | HTR6 (0.48) | PPARAPLA2G2APPARGHTR6BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689389-A4 | INDOLE COMPOUNDS | NAT HEALTH RESEARCH INSTITUTES (TW) | 2009-06-17 | — | — | EP | disclosed |
| US-7449478-B2 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2008-11-11 | — | — | US | disclosed |
| US-7449478-B2 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2008-11-11 | — | — | US | disclosed |
| US-7449478-B2 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2008-11-11 | — | — | US | disclosed |
| EP-1689389-A2 | INDOLE COMPOUNDS | National Health Research Institutes (TW) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005056522-A2 | INDOLE COMPOUNDS | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2005-06-23 | — | — | WO | disclosed |
| US-20050124675-A1 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2005-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124675-A1 | Indole compounds | PPARG, PPARD, PPARA | PPARA 3/4885ALDH1A1 338/4885KDM4E 2103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.