Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCAT2 | O15382 | 1/20 | 0.54 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.50 |
| ▸ | FEN1 | P39748 | 1/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | EIF4E | P06730 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.40 |
| ▸ | CTSA | P10619 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3035393 | 0.86 | PARP1 (0.48) | BCAT2ALOX5APFEN1SLC6A2SLC6A4 | |
| SCHEMBL4235118 | 0.86 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3NPC1RAB9A | |
| SCHEMBL3111889 | 0.84 | AR (0.55) | BCAT2ALOX5APFEN1CHEK1SLC6A2 | |
| SCHEMBL31621279 | 0.83 | SLC6A2 (0.64) | BCAT2ALOX5APFEN1CHEK1SLC6A2 | |
| SCHEMBL31621280 | 0.83 | SLC6A2 (0.64) | BCAT2ALOX5APFEN1CHEK1SLC6A2 | |
| SCHEMBL3035398 | 0.83 | BCAT2 (0.50) | BCAT2PARP1NPC1RAB9A | |
| SCHEMBL3040072 | 0.80 | AR (0.47) | SLC6A2SLC6A4SLC6A3PARP1TGFBR1 | |
| SCHEMBL3037599 | 0.80 | PARP1 (0.47) | ALOX5APFEN1PARP1 | |
| SCHEMBL3037606 | 0.77 | PARP1 (0.47) | PARP1 | |
| SCHEMBL3040077 | 0.77 | AR (0.44) | ALOX5APPARP1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2077998-A1 | PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008030466-A1 | PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2008-03-13 | — | — | WO | disclosed |