Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNASEH1 | O60930 | 5/20 | 0.42 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 2/20 | 0.35 |
| ▸ | CTSS | P25774 | 2/20 | 0.35 |
| ▸ | CTSK | P43235 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL51972 | 0.91 | RNASEH1 (0.42) | RNASEH1ERCC1FEN1ERCC4CTSB | |
| SCHEMBL52441 | 0.78 | RNASEH1 (0.45) | RNASEH1ERCC1FEN1ERCC4CTSB | |
| SCHEMBL63444 | 0.77 | RNASEH1 (0.43) | RNASEH1ERCC1FEN1ERCC4CTSB | |
| SCHEMBL9942868 | 0.77 | RNASEH1 (0.42) | RNASEH1ERCC1FEN1ERCC4CTSB | |
| SCHEMBL63358 | 0.76 | RNASEH1 (0.43) | RNASEH1ERCC1FEN1ERCC4CTSB | |
| SCHEMBL13691480 | 0.76 | RNASEH1 (0.43) | RNASEH1ERCC1FEN1ERCC4CTSB | |
| SCHEMBL51895 | 0.75 | RNASEH1 (0.42) | RNASEH1ERCC1FEN1ERCC4CTSB | |
| SCHEMBL2080700 | 0.75 | RNASEH1 (0.42) | RNASEH1ALDH1A1TNKSTNKS2 | |
| SCHEMBL63522 | 0.74 | RNASEH1 (0.41) | RNASEH1ERCC1FEN1ERCC4CTSB | |
| SCHEMBL62555 | 0.74 | RNASEH1 (0.43) | RNASEH1ERCC1FEN1ERCC4CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117540-A1 | BRIDGED HETEROCYCLES AS HIV INTEGRASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-09-24 | — | — | WO | disclosed |