Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 14/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.51 |
| ▸ | IGF1R | P08069 | 2/20 | 0.51 |
| ▸ | BRD4 | O60885 | 2/20 | 0.51 |
| ▸ | PLK1 | P53350 | 1/20 | 0.51 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.50 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4241310 | 0.93 | PTK2 (0.54) | PTK2AURKAAURKBLRRK2IGF1R | |
| SCHEMBL4237048 | 0.93 | PTK2 (0.57) | PTK2AURKAAURKBLRRK2IGF1R | |
| SCHEMBL4238376 | 0.93 | IGF1R (0.57) | PTK2AURKAAURKBLRRK2IGF1R | |
| SCHEMBL4240903 | 0.90 | PTK2 (0.55) | PTK2AURKAAURKBLRRK2IGF1R | |
| SCHEMBL4239695 | 0.90 | PTK2 (0.57) | PTK2AURKAAURKBLRRK2IGF1R | |
| SCHEMBL4234673 | 0.90 | PTK2 (0.56) | PTK2AURKAAURKBLRRK2IGF1R | |
| SCHEMBL4237026 | 0.89 | AURKA (0.57) | PTK2AURKAAURKBLRRK2IGF1R | |
| SCHEMBL4235459 | 0.89 | IGF1R (0.60) | PTK2AURKAAURKBLRRK2IGF1R | |
| SCHEMBL4242720 | 0.89 | PTK2 (0.55) | PTK2AURKAAURKBLRRK2IGF1R | |
| SCHEMBL4243514 | 0.89 | BRD4 (0.55) | PTK2AURKAAURKBLRRK2IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2100894-A1 | Pyridopyrimidines used as Plk1 (polo-like kinase) inhibitors | 4SC AG (DE) | 2009-09-16 | — | — | EP | disclosed |