Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.60 |
| ▸ | PLK1 | P53350 | 13/20 | 0.55 |
| ▸ | BRD4 | O60885 | 12/20 | 0.55 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.55 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.51 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.51 |
| ▸ | MAPK7 | Q13164 | 2/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
| ▸ | BRDT | Q58F21 | 5/20 | 0.51 |
| ▸ | RAD52 | P43351 | 1/20 | 0.51 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.50 |
| ▸ | PDXK | O00764 | 1/20 | 0.50 |
| ▸ | CIT | O14578 | 1/20 | 0.50 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.50 |
| ▸ | GAK | O14976 | 1/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.50 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.50 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4234109 | 0.95 | IGF1R (0.54) | IGF1RPLK1BRD4PTK2PLK3 | |
| SCHEMBL4241330 | 0.94 | IGF1R (0.53) | IGF1RPLK1BRD4PTK2LRRK2 | |
| SCHEMBL4380887 | 0.93 | IGF1R (0.63) | IGF1RPLK1BRD4PTK2LRRK2 | |
| SCHEMBL4235611 | 0.93 | IGF1R (0.64) | IGF1RPLK1BRD4PTK2LRRK2 | |
| SCHEMBL4238736 | 0.93 | IGF1R (0.51) | IGF1RPLK1BRD4PTK2LRRK2 | |
| SCHEMBL4223710 | 0.92 | IGF1R (0.50) | IGF1RPLK1BRD4PTK2LRRK2 | |
| SCHEMBL4238679 | 0.92 | IGF1R (0.50) | IGF1RPLK1BRD4PTK2DCLK1 | |
| SCHEMBL4234673 | 0.92 | PTK2 (0.56) | IGF1RPLK1BRD4PTK2LRRK2 | |
| SCHEMBL4246138 | 0.92 | IGF1R (0.49) | IGF1RPLK1BRD4PTK2LRRK2 | |
| SCHEMBL4238376 | 0.91 | IGF1R (0.57) | IGF1RBRD4PTK2LRRK2DCLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009112524-A1 | PYRIDOPYRIMIDINES AS PLK1 ( POLO-LIKE KINASE) INHIBITORS | 4SC AG (DE) | 2009-09-17 | — | — | WO | disclosed |
| EP-2100894-A1 | Pyridopyrimidines used as Plk1 (polo-like kinase) inhibitors | 4SC AG (DE) | 2009-09-16 | — | — | EP | disclosed |