Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2366104 | 0.80 | GPR119 (0.64) | GPR119CHEK2DDB1CRBNALDH1A1 | |
| SCHEMBL29223447 | 0.77 | CRBN (0.62) | GPR119CHEK2DDB1CRBNHRH3 | |
| SCHEMBL2735422 | 0.77 | GPR119 (0.67) | GPR119CHEK2ALDH1A1HRH3USP30 | |
| SCHEMBL74203 | 0.77 | GPR119 (0.67) | GPR119CHEK2ALDH1A1HRH3PDE4B | |
| SCHEMBL264162 | 0.77 | GPR119 (0.67) | GPR119CHEK2ALDH1A1HRH3USP30 | |
| SCHEMBL12533230 | 0.77 | GPR119 (0.67) | GPR119CHEK2ALDH1A1PDE4B | |
| SCHEMBL23373231 | 0.76 | GPR119 (0.63) | GPR119CHEK2ALDH1A1HRH3PDE4B | |
| SCHEMBL2951108 | 0.76 | GPR119 (0.63) | GPR119CHEK2ALDH1A1HRH3USP30 | |
| SCHEMBL2793124 | 0.76 | GPR119 (0.65) | GPR119CHEK2ALDH1A1HRH3 | |
| SCHEMBL2366151 | 0.76 | GPR119 (0.65) | GPR119CHEK2ALDH1A1HRH3PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069312-A2 | PYRIDIZINONE DERIVATIVES | Cephalon, Inc. (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008013838-A2 | PYRIDIZINONE DERIVATIVES | CEPHALON, INC. (US) | 2008-01-31 | — | — | WO | disclosed |