Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.50 |
| ▸ | PTK2 | Q05397 | 6/20 | 0.48 |
| ▸ | PLK1 | P53350 | 11/20 | 0.48 |
| ▸ | BRD4 | O60885 | 11/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.43 |
| ▸ | TAF1 | P21675 | 2/20 | 0.43 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.43 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | FES | P07332 | 2/20 | 0.43 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.43 |
| ▸ | CLK2 | P49760 | 2/20 | 0.43 |
| ▸ | NEK2 | P51955 | 2/20 | 0.43 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.43 |
| ▸ | CAMK2G | Q13555 | 2/20 | 0.43 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4238736 | 0.93 | IGF1R (0.51) | IGF1RPTK2PLK1BRD4PLK3 | |
| SCHEMBL4234109 | 0.92 | IGF1R (0.54) | IGF1RPTK2PLK1BRD4ALK | |
| SCHEMBL4235459 | 0.92 | IGF1R (0.60) | IGF1RPTK2PLK1BRD4ALK | |
| SCHEMBL4223710 | 0.92 | IGF1R (0.50) | IGF1RPTK2PLK1BRD4ALK | |
| SCHEMBL4380887 | 0.87 | IGF1R (0.63) | IGF1RPTK2PLK1BRD4ALK | |
| SCHEMBL4245451 | 0.87 | PTK2 (0.48) | IGF1RPTK2PLK1BRD4ALK | |
| SCHEMBL4245441 | 0.87 | PTK2 (0.48) | IGF1RPTK2PLK1BRD4ALK | |
| SCHEMBL4241330 | 0.86 | IGF1R (0.53) | IGF1RPTK2PLK1BRD4PLK3 | |
| SCHEMBL4235611 | 0.85 | IGF1R (0.64) | IGF1RPTK2PLK1BRD4BRDT | |
| SCHEMBL4234673 | 0.84 | PTK2 (0.56) | IGF1RPTK2PLK1BRD4BRDT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2100894-A1 | Pyridopyrimidines used as Plk1 (polo-like kinase) inhibitors | 4SC AG (DE) | 2009-09-16 | — | — | EP | disclosed |