Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 12/20 | 0.41 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4235468 | 0.85 | HTR6 (0.44) | HTR6RAPGEF4BRD4L3MBTL1PDE4A | |
| SCHEMBL4234116 | 0.85 | HTR6 (0.45) | HTR6RAPGEF4L3MBTL1PDE4APDE4B | |
| SCHEMBL31321816 | 0.84 | CA1 (0.39) | HTR6RAPGEF4BRD4L3MBTL1MEN1 | |
| SCHEMBL4233489 | 0.76 | KDM4E (0.48) | HTR6RAPGEF4BRD4L3MBTL1PDE4A | |
| SCHEMBL6753718 | 0.76 | HTR6 (0.61) | HTR6 | |
| SCHEMBL30275069 | 0.76 | HTR6 (0.45) | HTR6RAPGEF4L3MBTL1MEN1KMT2A | |
| SCHEMBL5998134 | 0.74 | HTR6 (0.54) | HTR6L3MBTL1PDE4APDE4BPDE4C | |
| SCHEMBL4225953 | 0.74 | HTR6 (0.35) | HTR6BRD4MEN1KMT2APKM | |
| SCHEMBL12359757 | 0.70 | PPARG (0.55) | HTR6RAPGEF4L3MBTL1PDE4APDE4B | |
| SCHEMBL3623475 | 0.70 | HTR6 (0.53) | HTR6MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009115874-A2 | NOVEL HETEROCYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | MATRIX LABORATORIES LTD. (IN) | 2009-09-24 | — | — | WO | disclosed |