Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2003424 | 0.76 | NPC1 (0.47) | HPGDNPC1RAB9ASMN1; SMN2TRPA1 | |
| Hydrochloric Acid SCHEMBL6053050 | 0.74 | NPC1 (0.50) | HPGDNPC1RAB9ASMN1; SMN2TRPA1 | |
| Hydrochloric Acid SCHEMBL9937789 | 0.74 | NPC1 (0.50) | HPGDNPC1RAB9ASMN1; SMN2TRPA1 | |
| Hydrochloric Acid SCHEMBL20640295 | 0.74 | NPC1 (0.50) | HPGDNPC1RAB9ASMN1; SMN2TRPA1 | |
| SCHEMBL3627225 | 0.74 | SIGMAR1 (0.38) | HPGDSIGMAR1LMNACYP2C19NOTUM | |
| SCHEMBL16452796 | 0.71 | NPC1 (0.46) | HPGDNPC1RAB9ASMN1; SMN2SIGMAR1 | |
| Phosphoric Acid SCHEMBL20600147 | 0.71 | NPC1 (0.43) | HPGDNPC1RAB9ASMN1; SMN2TRPA1 | |
| SCHEMBL30525283 | 0.70 | NPC1 (0.53) | HPGDNPC1RAB9ASMN1; SMN2TRPA1 | |
| SCHEMBL30525272 | 0.70 | NPC1 (0.53) | HPGDNPC1RAB9ASMN1; SMN2TRPA1 | |
| SCHEMBL4049974 | 0.70 | NPC1 (0.53) | HPGDNPC1RAB9ASMN1; SMN2TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107383019-B | Pyrazolo [4,3-h] quinazoline compounds and application thereof | 江苏艾凡生物医药有限公司 | 2019-10-15 | — | — | CN | disclosed |
| CN-107383019-A | Pyrazolo [4,3 h] quinazoline compounds and application thereof | 江苏艾凡生物医药有限公司 | 2017-11-24 | — | — | CN | disclosed |
| EP-2069315-A2 | QUINAZOLINONE AND ISOQUINOLINONE ACETAMIDE DERIVATIVES | N.V. Organon (NL) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008033764-A2 | QUINAZOLINONE AND ISOQUINOLINONE ACETAMIDE DERIVATIVES | N.V. ORGANON (NL) | 2008-03-20 | — | — | WO | disclosed |
| EP-1861380-A1 | 2-(4-OXO-4H-QUINAZOLIN-3-YL)ACETAMIDES AND THEIR USE AS VASOPRESSIN V3 ANTAGONISTS | N.V. Organon (NL) | 2007-12-05 | — | — | EP | disclosed |
| WO-2006095014-A1 | 2- (4-0X0-4H-QUINAZ0LIN-3-YL) ACETAMIDES AND THEIR USE AS VASOPRESSIN V3 ANTAGONISTS | N.V. ORGANON (NL) | 2006-09-14 | — | — | WO | disclosed |