Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 19/20 | 0.83 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.83 |
| ▸ | SOAT2 | O75908 | 4/20 | 0.65 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10197651 | 1.00 | DGAT1 (0.83) | DGAT1SOAT1SOAT2KDRCYP2C9 | |
| SCHEMBL423739 | 1.00 | DGAT1 (0.83) | DGAT1SOAT1SOAT2KDRCYP2C9 | |
| SCHEMBL10197659 | 0.91 | DGAT1 (1.00) | DGAT1SOAT1SOAT2 | |
| SCHEMBL461754 | 0.91 | DGAT1 (1.00) | DGAT1SOAT1SOAT2 | |
| SCHEMBL461755 | 0.91 | DGAT1 (1.00) | DGAT1SOAT1SOAT2 | |
| SCHEMBL10198329 | 0.89 | DGAT1 (0.86) | DGAT1SOAT1SOAT2 | |
| SCHEMBL10197337 | 0.89 | DGAT1 (0.83) | DGAT1SOAT1SOAT2KDR | |
| SCHEMBL10197648 | 0.88 | DGAT1 (0.64) | DGAT1SOAT1SOAT2 | |
| SCHEMBL13190146 | 0.84 | DGAT1 (0.77) | DGAT1SOAT1SOAT2KDRCYP2C9 | |
| SCHEMBL409194 | 0.81 | DGAT1 (0.82) | DGAT1SOAT1SOAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408744-A1 | BICYCLIC COMPOUNDS AS INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | Schering Corporation (US) | 2012-01-25 | — | — | EP | disclosed |
| WO-2010107768-A1 | BICYCLIC COMPOUNDS AS INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | SCHERING CORPORATION (US) | 2010-09-23 | — | — | WO | disclosed |