⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4478967 | 1.00 | — | — | |
| SCHEMBL18894377 | 1.00 | — | — | |
| SCHEMBL2292339 | 0.79 | — | — | |
| SCHEMBL3389566 | 0.78 | TSHR (0.64) | — | |
| SCHEMBL28182 | 0.78 | — | — | |
| SCHEMBL1638758 | 0.78 | — | — | |
| SCHEMBL102859 | 0.78 | — | — | |
| SCHEMBL2700308 | 0.78 | TSHR (0.64) | — | |
| SCHEMBL1593359 | 0.78 | TSHR (0.64) | — | |
| SCHEMBL8036941 | 0.78 | TSHR (0.64) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 294 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024012557-A1 | ANTI-APOPTOTIC BCL-2 FAMILY PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | BERRYBIO (HONG KONG) LIMITED (CN) | 2024-01-18 | — | — | WO | claimed |
| CN-110358120-A | A kind of preparation method and product of ultra-thin ultralow shrinking percentage graphene polyimides heat conducting film | 江苏亚宝绝缘材料股份有限公司 | 2019-10-22 | — | — | CN | claimed |
| US-8466295-B2 | Thiophene derivatives as factor XIa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-06-18 | — | — | US | claimed |
| US-8455521-B2 | Diaminoalkane aspartic protease inhibitors | VITAE PHARMACEUTICALS, INC. (US) | 2013-06-04 | — | — | US | claimed |
| US-20120270853-A1 | ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2012-10-25 | — | — | US | claimed |
| US-8252830-B2 | Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor XIa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-08-28 | — | — | US | claimed |
| US-8163749-B2 | Six-membered heterocycles useful as serine protease inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-04-24 | — | — | US | claimed |
| US-8106221-B2 | Renin inhibitors | VITAE PHARMACEUTICALS, INC. (US) | 2012-01-31 | — | — | US | claimed |
| EP-1981854-B1 | ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2011-06-01 | — | — | EP | claimed |
| CN-101072561-B | Diaminoalkane aspartic protease inhibitors | VITAE PHARMACEUTICALS INC | 2011-05-11 | — | — | CN | claimed |
| EP-1157029-A1 | OLIGOPEPTIDE DERIVATIVES FOR THE ELECTROCHEMICAL MEASUREMENT OF PROTEASE ACTIVITY | Pentapharm AG (CH) | 2001-11-28 | — | — | EP | claimed |
| WO-2000050446-A1 | OLIGOPEPTIDE DERIVATIVES FOR THE ELECTROCHEMICAL MEASUREMENT OF PROTEASE ACTIVITY | PENTAPHARM AG (CH) | 2000-08-31 | — | — | WO | claimed |
| EP-0128118-B1 | PEPTIDE DERIVATIVES AND THEIR USE AS SUBSTRATES IN THE QUANTITATIVE DETERMINATION OF ENZYMES | Pentapharm A.G. (CH) | 1991-08-14 | — | — | EP | claimed |
| US-4629695-A | Peptide derivatives and use thereof as substrates for quantitatively assaying enzymes | PENTAPHARM A.G. (CH) | 1986-12-16 | — | — | US | claimed |
| EP-0078764-B1 | PROCESS FOR THE QUANTITATIVE DETERMINATION OF THE BLOOD CLOTTING FACTOR XII IN HUMAN PLASMA | Pentapharm A.G. (CH) | 1986-01-02 | — | — | EP | claimed |
| US-4480030-A | BLOOD-COAGULATION FACTOR XA | PENTAPHARM A.G. (CH) | 1984-10-30 | — | — | US | claimed |
| US-4440678-A | ARGININES | PENTAPHARM, A.G. (CH) | 1984-04-03 | — | — | US | claimed |
| EP-0034122-B1 | TRIPEPTIDE DERIVATIVES AND THEIR USE IN THE DETERMINATION OF ENZYMES | Pentapharm A.G. (CH) | 1983-09-21 | — | — | EP | claimed |
| WO-1981002294-A1 | TRIPEPTIDIC DERIVATIVES AND USE THEREOF FOR ENZYME DETERMINATION | PENTAPHARM AG (CH) | 1981-08-20 | — | — | WO | claimed |
| EP-0034122-A1 | Tripeptide derivatives and their use in the determination of enzymes | Pentapharm A.G. (CH) | 1981-08-19 | — | — | EP | claimed |