Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 17/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 17/20 | 0.45 |
| ▸ | JAK3 | P52333 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4238672 | 1.00 | HCRTR1 (0.45) | HCRTR1HCRTR2JAK3 | |
| SCHEMBL8227805 | 0.97 | HCRTR1 (0.45) | HCRTR1HCRTR2JAK3 | |
| SCHEMBL4241693 | 0.91 | HCRTR1 (0.49) | HCRTR1HCRTR2JAK3 | |
| SCHEMBL4241690 | 0.91 | HCRTR1 (0.49) | HCRTR1HCRTR2JAK3 | |
| SCHEMBL4243932 | 0.89 | HCRTR1 (0.50) | HCRTR1HCRTR2 | |
| SCHEMBL4243925 | 0.89 | HCRTR1 (0.50) | HCRTR1HCRTR2 | |
| SCHEMBL3708656 | 0.80 | HCRTR1 (0.46) | HCRTR1HCRTR2 | |
| SCHEMBL4243256 | 0.80 | HCRTR1 (0.51) | HCRTR1HCRTR2 | |
| SCHEMBL4243262 | 0.80 | HCRTR1 (0.51) | HCRTR1HCRTR2 | |
| SCHEMBL4239234 | 0.77 | CCNK (0.44) | JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897627-B2 | Heteroaryl derivatives as orexin receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2011-03-01 | — | — | US | claimed |
| US-20090163485-A1 | HETEROARYL DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-25 | — | — | US | claimed |
| US-7897627-B2 | Heteroaryl derivatives as orexin receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2011-03-01 | — | — | US | disclosed |
| US-20090163485-A1 | HETEROARYL DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163485-A1 | HETEROARYL DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | HCRTR1, HCRTR2, MTNR1A | HCRTR1 1/4885HCRTR2 2/4885JAK3 1924/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.