Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | VCP | P55072 | 4/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 3/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | F11 | P03951 | 1/20 | 0.33 |
| ▸ | F7 | P08709 | 1/20 | 0.33 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL41795 | 0.90 | MEN1 (0.35) | HSD17B10DRD4MAPTHTR1APARP1 | |
| SCHEMBL45171 | 0.83 | HSD17B10 (0.41) | VCPHSD17B10DRD4MAPTLMNA | |
| SCHEMBL45170 | 0.83 | HSD17B10 (0.41) | VCPHSD17B10DRD4MAPTLMNA | |
| SCHEMBL41668 | 0.79 | HDAC4 (0.46) | HDAC4HSD17B10F10F11F7 | |
| SCHEMBL45394 | 0.75 | PRKD1 (0.40) | HSD17B10MAPTHTR1ADRD3 | |
| SCHEMBL45313 | 0.75 | PRKD1 (0.40) | HSD17B10MAPTLMNAHTR1ADRD3 | |
| SCHEMBL45444 | 0.73 | HSD17B10 (0.42) | HSD17B10DRD4MAPTHTR1APOLB | |
| SCHEMBL45445 | 0.73 | HSD17B10 (0.42) | HSD17B10DRD4MAPTHTR1APOLB | |
| SCHEMBL15752185 | 0.72 | HDAC4 (0.44) | HDAC4LMNA | |
| SCHEMBL45312 | 0.72 | F10 (0.47) | MAPTLMNAF10F11F7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588458-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-08 | — | — | EP | claimed |
| WO-2012001020-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-05 | — | — | WO | claimed |
| EP-2588458-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012001020-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-05 | — | — | WO | disclosed |