Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.35 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.35 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL42389 | 0.90 | HDAC4 (0.36) | HSD17B10DRD4HTR1APOLBMAPT | |
| SCHEMBL45313 | 0.85 | PRKD1 (0.40) | MEN1RAB9AKMT2AHSD17B10NTRK1 | |
| SCHEMBL45394 | 0.85 | PRKD1 (0.40) | MEN1RAB9AKMT2AHSD17B10NTRK1 | |
| SCHEMBL45444 | 0.83 | HSD17B10 (0.42) | MEN1RAB9AKMT2AHSD17B10DRD4 | |
| SCHEMBL45445 | 0.83 | HSD17B10 (0.42) | MEN1RAB9AKMT2AHSD17B10DRD4 | |
| SCHEMBL11026483 | 0.81 | F10 (0.45) | MEN1KMT2ANTRK1NTRK3NTRK2 | |
| SCHEMBL45257 | 0.80 | PRMT5 (0.44) | MEN1RAB9AKMT2ANTRK1NTRK3 | |
| SCHEMBL45312 | 0.79 | F10 (0.47) | CYP2C19CYP2C9MAPTHDAC3CYP1A2 | |
| SCHEMBL45003 | 0.79 | F10 (0.39) | NTRK1NTRK3NTRK2CYP2C19MAPT | |
| SCHEMBL41549 | 0.78 | KMO (0.52) | MEN1KMT2AHSD17B10CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588458-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-08 | — | — | EP | claimed |
| WO-2012001020-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-05 | — | — | WO | claimed |