Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.42 |
| ▸ | PDE7A | Q13946 | 12/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4237270 | 0.81 | PIK3CD (0.49) | PIK3CDALDH1A1CYP1A2TSHRCYP2C9 | |
| SCHEMBL4227217 | 0.72 | SMN1; SMN2 (0.46) | PIK3CDALDH1A1CYP1A2TSHRCYP2C9 | |
| SCHEMBL4228491 | 0.71 | NPC1 (0.53) | PIK3CDALDH1A1CYP1A2TSHRCYP2C9 | |
| SCHEMBL4237005 | 0.70 | NPC1 (0.46) | PIK3CDALDH1A1CYP1A2TSHRCYP2C9 | |
| SCHEMBL4242198 | 0.70 | PIK3CD (0.56) | PIK3CDPDE7APDE4BPDE4APDE4C | |
| SCHEMBL4229018 | 0.69 | SMN1; SMN2 (0.42) | PIK3CDPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4242355 | 0.68 | PIK3CD (0.57) | PIK3CDPDE7APDE4BPDE4APDE4C | |
| SCHEMBL4227286 | 0.67 | NPC1 (0.46) | PIK3CDALDH1A1CYP1A2TSHRCYP2C9 | |
| SCHEMBL1703780 | 0.67 | NPC1 (0.45) | PIK3CDPDE7APDE4BALDH1A1CYP1A2 | |
| SCHEMBL7512190 | 0.64 | PIK3CD (0.54) | PIK3CDPDE7APDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097422-A1 | THIENOPYRIMIDINONES FOR TREATMENT OF INFLAMMATORY DISORDERS AND CANCERS | Eli Lilly & Co. (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008064018-A1 | THIENOPYRIMIDINONES FOR TREATMENT OF INFLAMMATORY DISORDERS AND CANCERS | ELI LILLY & CO. (US) | 2008-05-29 | — | — | WO | disclosed |