SCHEMBL4239365

SCHEMBL4239365

N=C(N)c1cccc(NC(=O)NCC(=O)NCc2cccc(Br)c2)c1

nearest known ligand 0.82

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
F7 P08709 9/20 0.82
F10 P00742 5/20 0.82
F2 P00734 4/20 0.55
MTOR P42345 1/20 0.49
PARP1 P09874 1/20 0.47
C1S P09871 1/20 0.45
HPN P05981 1/20 0.45
PRSS1 P07477 1/20 0.45
PRSS2 P07478 1/20 0.45
PRSS3 P35030 1/20 0.45
HGFAC Q04756 1/20 0.45
ST14 Q9Y5Y6 1/20 0.45
ROCK2 O75116 1/20 0.44
ITGB3 P05106 1/20 0.43
ITGA2B P08514 1/20 0.43
TSHR P16473 1/20 0.43
NPC1 O15118 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL236558 0.90 F7 (1.00) F7F10F2MTOR
Hydrochloric Acid SCHEMBL234684 0.89 F7 (0.98) F7F10F2MTOR
SCHEMBL13855065 0.83 F10 (0.58) F7F10F2PARP1C1S
SCHEMBL13993085 0.83 F7 (0.72) F7F10F2MTORNPC1
SCHEMBL4961414 0.80 F7 (0.67) F7F10F2MTORNPC1
SCHEMBL4420144 0.77 F7 (1.00) F7F10F2ROCK2
Hydrochloric Acid SCHEMBL6365169 0.75 ITGB3 (0.60) F7F10F2PRSS1PRSS2
Amicarbalide SCHEMBL1818799 0.74 PLAU (0.65) F10F2HPNPRSS1PRSS2
SCHEMBL13855059 0.73 F7 (0.70) F7F10F2MTORNPC1
SCHEMBL10320867 0.73 F10 (0.57) F7F10MTORTSHRNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090130085-A1 Amidino-Compounds for Stabilizing Factor VII Polypeptide Formulations NOVO NORDISH HEALTHCARE AG (CH) 2009-05-21 US disclosed
US-20090130085-A1 Amidino-Compounds for Stabilizing Factor VII Polypeptide Formulations NOVO NORDISH HEALTHCARE AG (CH) 2009-05-21 US disclosed
US-20090130085-A1 Amidino-Compounds for Stabilizing Factor VII Polypeptide Formulations NOVO NORDISH HEALTHCARE AG (CH) 2009-05-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090130085-A1 Amidino-Compounds for Stabilizing Factor VII Polypeptide Formulations F7, F5, F8 F7 1/4885F10 15/4885F2 9/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.