⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2846020 | 0.92 | — | — | |
| SCHEMBL10908427 | 0.81 | — | — | |
| SCHEMBL4554124 | 0.79 | — | — | |
| SCHEMBL24761128 | 0.78 | — | — | |
| SCHEMBL1666618 | 0.77 | TRPV1 (0.35) | — | |
| SCHEMBL8578846 | 0.75 | TDP1 (0.32) | — | |
| SCHEMBL16500031 | 0.75 | FOLH1 (0.39) | — | |
| SCHEMBL8735841 | 0.73 | TRPV1 (0.40) | — | |
| SCHEMBL21624976 | 0.73 | TRPV1 (0.40) | — | |
| SCHEMBL8777953 | 0.73 | TRPV1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214933-A1 | METHOD FOR MODULATING THE METABOLISM OF NITROGEN OXIDES, COMPOSITIONS THEREFOR (AND VARIANTS) AND METHOD FOR ACTING ON A PATIENT'S ORGANISM NECESSITATING THE METABOLISM OF NITROGEN OXIDES TO BE CORRECTED | Institut Molekulyarnoi Genetiki Rossiiskoi Akademii Nauk ( Img Ran ) (RU) | 2002-06-19 | — | — | EP | claimed |
| EP-1054664-A1 | METHOD FOR MODULATING MACROPHAGE ACTIVATION | Neurochem, Inc. (CA) | 2000-11-29 | — | — | EP | claimed |
| WO-1999040909-A1 | METHOD FOR MODULATING MACROPHAGE ACTIVATION | NEUROCHEM, INC. (CA) | 1999-08-19 | — | — | WO | claimed |
| WO-2009117042-A1 | USE OF PYRENE TO CARRY NON-PEPTIDE AGENTS ACROSS THE BLOOD BRAIN BARRIER | ADLYFE, INC. (US) | 2009-09-24 | — | — | WO | disclosed |
| EP-1054664-A1 | METHOD FOR MODULATING MACROPHAGE ACTIVATION | Neurochem, Inc. (CA) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999040909-A1 | METHOD FOR MODULATING MACROPHAGE ACTIVATION | NEUROCHEM, INC. (CA) | 1999-08-19 | — | — | WO | disclosed |
| EP-0814842-A1 | METHOD FOR TREATING AMYLOIDOSIS | Queen's University at Kingston (CA) | 1998-01-07 | — | — | EP | disclosed |
| WO-1996039129-A1 | METHODS OF INCREASING AMYLOID DEPOSITION | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 1996-12-12 | — | — | WO | disclosed |
| WO-1996028187-A1 | METHOD FOR TREATING AMYLOIDOSIS | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 1996-09-19 | — | — | WO | disclosed |