Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VHL | P40337 | 1/20 | 0.61 |
| ▸ | ELOC | Q15369 | 1/20 | 0.61 |
| ▸ | ELOB | Q15370 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 7/20 | 0.53 |
| ▸ | NSD2 | O96028 | 1/20 | 0.53 |
| ▸ | GRK2 | P25098 | 1/20 | 0.53 |
| ▸ | CASP6 | P55212 | 1/20 | 0.53 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.53 |
| ▸ | AOC2 | O75106 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 7/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20319186 | 0.80 | VHL (0.67) | VHLELOCELOBPOLBNSD2 | |
| SCHEMBL28801815 | 0.79 | VHL (0.59) | VHLELOCELOBPOLBNSD2 | |
| SCHEMBL4049582 | 0.76 | VHL (1.00) | VHLELOCELOBPOLBNSD2 | |
| SCHEMBL16242550 | 0.76 | VHL (0.61) | VHLELOCELOBPOLBNSD2 | |
| SCHEMBL5603565 | 0.76 | VHL (0.61) | VHLELOCELOBPOLBNSD2 | |
| SCHEMBL112197 | 0.76 | VHL (0.61) | VHLELOCELOBPOLBNSD2 | |
| SCHEMBL13461836 | 0.76 | VHL (0.61) | VHLELOCELOBPOLBNSD2 | |
| SCHEMBL1260586 | 0.76 | VHL (0.61) | VHLELOCELOBPOLBNSD2 | |
| SCHEMBL6057565 | 0.73 | HDAC1 (0.50) | POLBL3MBTL1MEN1KMT2AALDH1A1 | |
| SCHEMBL5601606 | 0.73 | VHL (0.57) | VHLELOCELOBPOLBNSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106536508-A | ISOINDOLINE-1-ONE DERIVATIVES AS CHOLINERGIC MUSCARINIC M1 RECEPTOR POSITIVE ALLOESTERIC MODULATOR ACTIVITY FOR THE TREATMENT OF ALZHEIMERS DISEASE | 武田药品工业株式会社 | 2017-03-22 | — | — | CN | disclosed |
| WO-2009109999-A1 | NOVEL PROTEIN TYROSINE PHOSPHATASE - IB INHIBITORS | LUPIN LIMITED (IN) | 2009-09-11 | — | — | WO | disclosed |