SCHEMBL4240933

SCHEMBL4240933

Cc1cc(F)cc(N=C=O)c1

nearest known ligand 0.41

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.41
TRPA1 O75762 1/20 0.41
MAPK1 P28482 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
RAPGEF4 Q8WZA2 2/20 0.34
TSHR P16473 1/20 0.33
ACHE P22303 1/20 0.32
FFAR4 Q5NUL3 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL159581 0.84 MAPK1 (0.41) CYP3A4TRPA1MAPK1TDP1TSHR
SCHEMBL59852 0.84 CYP3A4 (0.48) CYP3A4TRPA1MAPK1TDP1TSHR
SCHEMBL109084 0.84 CYP3A4 (0.48) CYP3A4TRPA1MAPK1TDP1TSHR
Benzene SCHEMBL28982643 0.80 CYP3A4 (0.45) CYP3A4TRPA1MAPK1TDP1TSHR
SCHEMBL7002811 0.78 CYP3A4 (0.44) CYP3A4TRPA1MAPK1TDP1TSHR
SCHEMBL28861481 0.76 ACHE (0.36) RAPGEF4ACHEFFAR4
Isothiocyanate SCHEMBL3612486 0.75 MAPK1 (0.35) CYP3A4TRPA1MAPK1TDP1TSHR
SCHEMBL5444503 0.75 MAPK1 (0.44) CYP3A4TRPA1MAPK1TDP1RAPGEF4
SCHEMBL7921988 0.75 MAPK1 (0.44) CYP3A4TRPA1MAPK1TDP1RAPGEF4
SCHEMBL16368740 0.75 CYP3A4 (0.38) CYP3A4TRPA1MAPK1TDP1RAPGEF4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090216006-A1 COVALENTLY BOUND POLYSACCHARIDE-BASED CHIRAL STATIONARY PHASES AND METHOD FOR THEIR PREPARATION XU HUI 2009-08-27 US claimed
EP-4460492-A1 COMPOUNDS CONTAINING A HYDROXYPHENYL MOIETY AND THEIR USE (INSERM) Institut National de la Santé et de la Recherche Médicale (FR) 2024-11-13 EP disclosed
WO-2023131677-A1 COMPOUNDS CONTAINING A HYDROXYPHENYL MOIETY AND THEIR USE INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2023-07-13 WO disclosed
WO-2023131677-A1 COMPOUNDS CONTAINING A HYDROXYPHENYL MOIETY AND THEIR USE INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2023-07-13 WO disclosed
US-20090216006-A1 COVALENTLY BOUND POLYSACCHARIDE-BASED CHIRAL STATIONARY PHASES AND METHOD FOR THEIR PREPARATION XU HUI 2009-08-27 US disclosed