Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 9/20 | 0.53 |
| ▸ | DRD2 | P14416 | 7/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.41 |
| ▸ | DRD4 | P21917 | 5/20 | 0.41 |
| ▸ | DRD3 | P35462 | 5/20 | 0.41 |
| ▸ | PER2 | O15055 | 1/20 | 0.40 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4230639 | 0.80 | CHRM1 (0.52) | CHRM1DRD2GRIN1GRIN2BDRD4 | |
| SCHEMBL5389753 | 0.79 | DRD2 (0.62) | CHRM1DRD2GRIN1GRIN2BCHRM2 | |
| SCHEMBL5653475 | 0.79 | DRD2 (0.41) | CHRM1DRD2GRIN1GRIN2BCHRM2 | |
| SCHEMBL4052063 | 0.76 | GAA (0.49) | CHRM1DRD2KCNH2CHRM5CHRM3 | |
| SCHEMBL14419535 | 0.76 | — | — | |
| SCHEMBL10508437 | 0.75 | CHRM1 (0.48) | CHRM1DRD2KCNH2HDAC6HDAC8 | |
| SCHEMBL1764224 | 0.75 | DRD2 (0.60) | CHRM1DRD2GRIN1GRIN2BCHRM2 | |
| SCHEMBL4101050 | 0.74 | CHRM1 (0.53) | CHRM1DRD2KCNH2GRIN1GRIN2B | |
| SCHEMBL5384961 | 0.74 | DRD2 (0.59) | CHRM1DRD2GRIN1GRIN2BCHRM2 | |
| SCHEMBL8556641 | 0.73 | SRD5A1 (0.55) | CHRM1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106534-A1 | NOVEL HETEROCYCLIC CARBOXAMIDES AS M1 AGONISTS | H. LUNDBECK A/S (DK) | 2009-09-03 | — | — | WO | disclosed |
| WO-2009106534-A1 | NOVEL HETEROCYCLIC CARBOXAMIDES AS M1 AGONISTS | H. LUNDBECK A/S (DK) | 2009-09-03 | — | — | WO | disclosed |