Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 11/20 | 1.00 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 5/20 | 0.64 |
| ▸ | RAB9A | P51151 | 5/20 | 0.64 |
| ▸ | LMNA | P02545 | 5/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | GFER | P55789 | 1/20 | 0.64 |
| ▸ | MPL | P40238 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.60 |
| ▸ | RELA | Q04206 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29530821 | 0.91 | ADORA3 (1.00) | ADORA3RXFP1SMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL6942413 | 0.84 | ADORA3 (1.00) | ADORA3RXFP1SMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL10248489 | 0.83 | ADORA3 (0.78) | ADORA3RXFP1SMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL9852174 | 0.82 | ADORA3 (0.77) | ADORA3RXFP1SMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL2304853 | 0.80 | ADORA3 (0.74) | ADORA3RXFP1SMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL20458189 | 0.79 | ADORA3 (0.72) | ADORA3RXFP1SMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL16254958 | 0.79 | SMN1; SMN2 (1.00) | ADORA3RXFP1SMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL22622063 | 0.78 | ADORA3 (0.70) | ADORA3RXFP1SMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL9892965 | 0.78 | SMN1; SMN2 (0.78) | ADORA3RXFP1SMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL18094533 | 0.78 | ADORA3 (0.69) | ADORA3RXFP1SMN1; SMN2L3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009010871-A2 | PYRAZOLE DERIVATIVES AS ANTAGONISTS OF ADENOSINE A3 RECEPTOR | ADDEX PHARMA S.A. (CH) | 2009-01-22 | — | — | WO | disclosed |