Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 4/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | GNRHR | P30968 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4244502 | 1.00 | KIF11 (0.42) | KIF11BRD4CCNCCDK8GNRHR | |
| SCHEMBL4253648 | 0.89 | BRD4 (0.39) | KIF11BRD4CCNCCDK8GNRHR | |
| SCHEMBL4253643 | 0.89 | BRD4 (0.39) | KIF11BRD4CCNCCDK8GNRHR | |
| SCHEMBL4252736 | 0.87 | KIF11 (0.40) | KIF11BRD4CCNCCDK8GNRHR | |
| SCHEMBL4252742 | 0.87 | KIF11 (0.40) | KIF11BRD4CCNCCDK8GNRHR | |
| SCHEMBL4251287 | 0.82 | KMT2A (0.39) | KIF11MAPT | |
| SCHEMBL4251290 | 0.82 | KMT2A (0.39) | KIF11MAPT | |
| SCHEMBL4244969 | 0.81 | KIF11 (0.62) | KIF11 | |
| SCHEMBL4256010 | 0.80 | KIF11 (0.56) | KIF11 | |
| SCHEMBL4244578 | 0.80 | KIF11 (0.55) | KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035426-A1 | PYRAZOLOPYRIMIDONES | 4SC AG (DE) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007144384-A1 | PYRAZOLOPYRIMIDONES | 4SC AG (DE) | 2007-12-21 | — | — | WO | disclosed |