SCHEMBL4244933

SCHEMBL4244933

Brc1ccc(CNCCN2CCOCC2)cc1

nearest known ligand 0.60

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.60
CYP2D6 P10635 2/20 0.57
CYP3A4 P08684 1/20 0.57
CYP2C19 P33261 1/20 0.57
ALDH1A1 P00352 3/20 0.54
TNKS2 Q9H2K2 1/20 0.52
DPP7 Q9UHL4 2/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
DRD2 P14416 1/20 0.51
DRD3 P35462 1/20 0.51
TSHR P16473 2/20 0.50
LMNA P02545 1/20 0.48
MAPT P10636 1/20 0.48
MPI P34949 1/20 0.48
POLB P06746 1/20 0.47
CNR1 P21554 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3166127 0.92 CYP2D6 (0.65) KMT2ACYP2D6CYP3A4CYP2C19ALDH1A1
SCHEMBL3179723 0.86 CYP2C19 (0.76) KMT2ACYP2D6CYP3A4CYP2C19ALDH1A1
SCHEMBL6205018 0.84 CYP2D6 (0.57) KMT2ACYP2D6CYP3A4CYP2C19ALDH1A1
SCHEMBL27550438 0.84 CYP2D6 (0.57) KMT2ACYP2D6CYP3A4CYP2C19ALDH1A1
SCHEMBL12093346 0.84 POLB (0.60) CYP2D6CYP3A4CYP2C19ALDH1A1TNKS2
SCHEMBL14782117 0.84 CYP2D6 (0.57) KMT2ACYP2D6CYP3A4CYP2C19ALDH1A1
SCHEMBL39631 0.84 DPP7 (0.73) KMT2ACYP2D6CYP3A4CYP2C19ALDH1A1
Hydrochloric Acid SCHEMBL5758788 0.83 DPP7 (0.71) KMT2ACYP2D6CYP3A4CYP2C19ALDH1A1
Hydrochloric Acid SCHEMBL7000083 0.83 DPP7 (0.71) KMT2ACYP2D6CYP3A4CYP2C19ALDH1A1
SCHEMBL4243253 0.82 L3MBTL1 (0.53) KMT2ACYP2D6CYP3A4CYP2C19ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2049118-A1 MORPHOLINYL AND PYRROLIDINYL ANALOGS SmithKline Beecham Corporation (US) 2009-04-22 EP disclosed
WO-2008011551-A1 MORPHOLINYL AND PYRROLIDINYL ANALOGS SMITHKLINE BEECHAM CORPORATION (US) 2008-01-24 WO disclosed